沉默信息调节因子在重金属健康损害中的作用及机制研究进展  

Research progress of roles and mechanism of action of sirtuins in health damage induced by heavy metals

作　　者：喻林峰 曹晓霖 刘梦妍 李婕 YU Lin-feng;CAO Xiao-lin;LIU Meng-yan;LI Jie(School of Public Health,Capital Medical University,Beijing 100069,China;Beijing Key Laboratory of Environment and Aging,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学公共卫生学院,北京100069 [2]首都医科大学环境与衰老北京市重点实验室,北京100069

出　　处：《环境卫生学杂志》2025年第4期331-338,344,共9页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：国家自然科学基金(82103797);北京市教育委员会科技计划一般项目(KM202210025026)。

摘　　要：重金属广泛存在于水、土壤、空气中,可以通过摄入、吸入等途径进入机体。重金属暴露威胁人体健康。沉默信息调节因子(sirtuins,SIRT)是一类烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD+)依赖性组蛋白去乙酰酶,调控细胞内多种生物过程的关键信号通路。近年来,重金属暴露对SIRT蛋白家族影响的研究逐渐增多。本文综述SIRT家族在重金属暴露致健康损害的作用机制,为环境重金属污染的预防和中毒的机制探讨提供参考。Heavy metals are widely present in water,soil,and air and can enter the body through ingestion,inhalation,and other pathways.Exposure to heavy metals poses a serious threat to human health.Sirtuins(SIRT)are a class of nicotinamide adenine dinucleotide-dependent histone deacetylases that regulate key signaling pathways for various biological processes in cells.In recent years,there are increasing studies on the roles of SIRT family in adverse effects induced by heavy metal exposure.This study reviews the mechanism of action of SIRT family in health damage caused by heavy metal exposure,providing a reference for the prevention of environmental heavy metal pollution and the exploration of poisoning mechanisms.

关 键 词：沉默信息调节因子(SIRT) 重金属 氧化应激 细胞凋亡 炎症 

分 类 号：R114[医药卫生—卫生毒理学] R12[医药卫生—公共卫生与预防医学]