基于两样本孟德尔随机化探讨白细胞端粒长度与前列腺炎、睾丸炎和附睾炎的因果关系  

Exploring the causal relationship between leukocyte telomere length and prostatitis,orchitis,and epididymitis based on a two-sample Mendelian randomization

作　　者：李丹杨 余顺 杨博辉 张君宝 尹国臣 吴林纳 董芹作 徐金龙 宁树平 赵荣 LI Dan-yang;YU Shun;YANG Bo-hui;ZHANG Jun-bao;YIN Guo-chen;WU Lin-na;DONG Qin-zuo;XU Jin-long;NING Shu-ping;ZHAO Rong(Second School of Clinical Medicine,Yunnan University of Chinese Medicine,Kunming,Yunnan 650500,China;First School of Clinical Medicine,Yunnan University of Chinese Medicine,Kunming,Yunnan 650500,China;Department of Acupuncture Binchuan Hospital of Traditional Chinese Medicine,Dali,Yunnan 671600,China)

机构地区：[1]云南中医药大学第二临床医学院,云南昆明650500 [2]云南中医药大学第一临床医学院,云南昆明650500 [3]宾川县中医医院针灸科,云南大理671600

出　　处：《中华男科学杂志》2025年第4期306-312,共7页National Journal of Andrology

基　　金：国家自然科学基金(82060895);云南省2020年高层次中医药领军人才:云卫中医发展发[2021]1号;云南省“万人计划”名医专项(YNWR-MY-2018-052);云南省教育厅科学研究基金(2023Y0431,2024Y407,2023Y0465,2025Y0640)。

摘　　要：目的:运用两样本孟德尔随机化(MR)方法,探讨白细胞端粒长度与前列腺炎、睾丸炎及附睾炎3种男科疾病之间的遗传因果关系。方法:通过挖掘全基因组关联研究数据库(GWAS)数据,将白细胞端粒长度作为暴露因素,而前列腺炎、睾丸炎及附睾炎则作为结局因素。采用逆方差加权法(IVW)作为主要分析方法,加权中位数法和MR-Egger回归作为辅助分析方法,对白细胞端粒长度和3种男科疾病之间的因果关联进行孟德尔随机化的分析。采用MR-Egger截距法检验水平多效性,采用留一法进行灵敏度分析。结果:共筛选了121个相关的SNP。白细胞端粒长度是前列腺炎的危险因素(OR=1.383,95%CI:1.044~1.832;P=0.024),白细胞端粒长度是睾丸炎和附睾炎的危险因素(OR=1.770,95%CI:1.275~2.456,P=0.000 6)。结论:MR分析提供的遗传证据表明,随着白细胞端粒长度的缩短会降低患前列腺炎、睾丸炎和附睾炎的风险。Objective:To investigate the genetic causal relationship of leukocyte telomere length(LTL) with prostatitis,orchitis and epididymitis by two-sample Mendelian randomization(MR).Methods:Using LTL as the exposure factor and prostatitis,orchitis and epididymitis as outcome factors,we mined the Database of Genome-Wide Association Studies(GWAS).Then,we analyzed the causal relationship of LTL with prostatitis,orchitis and epididymitis by Mendelian randomization using inverse variance weighting(IVW) as the main method and weighted median and MR-Egger regression as auxiliary methods,determined the horizontal multiplicity by MR-Egger intercept test,and conducted sensitivity analysis using the leaving-one-out method.Results:A total of 121 related single nucleotide polymorphisms(SNPs) were identified in this study.IVW showed LTL to be a risk factor for prostatitis(OR = 1.383,95% CI:1.044-1.832,P = 0.024),and for orchitis and epididymitis as well(OR = 1.770,95% CI:1.275-2.456,P = 0.000 6).Conclusion:Genetic evidence from Mendelian randomized analysis indicates that shortening of LTL reduces the risk of prostatitis,orchitis and epididymitis.

关 键 词：孟德尔随机化 前列腺炎 睾丸炎 附睾炎 端粒长度 

分 类 号：R697[医药卫生—泌尿科学]