肥胖对雄性生殖功能的影响及机制研究进展  

Impact and action mechanisms of obesity on male reproductive function:An update

作　　者：魏冉 郎哲涛(综述) 王二辉(审校) WEI Ran;LANG Zhe-tao;WANG Er-hui(Department of Nursing,School of Medicine,Shaoxing College of Arts and Sciences,Shaoxing,Zhejiang 312000,China)

机构地区：[1]绍兴文理学院医学院护理系,浙江绍兴312000

出　　处：《中华男科学杂志》2025年第4期357-362,共6页National Journal of Andrology

基　　金：国家自然科学基金(81703230);浙江省医药卫生科技计划项目(2025KY1704)。

摘　　要：肥胖对雄性生殖功能的不利影响主要表现在生殖系统发育异常、睾酮水平降低、精子质量下降和影响子代健康等几个方面,但其调控作用机制远未阐明。本文从人群流行病学和动物实验两个方面阐述肥胖对雄性生殖系统的影响,并从下丘脑-垂体-睾丸轴、血-睾屏障、炎症反应、氧化应激、睾丸生殖细胞凋亡和父源性肥胖对子代健康的影响等角度对相关作用机制进行综述,为预防和治疗肥胖相关男性生殖功能损伤提供参考。The adverse effects of obesity on male reproductive function are mainly manifested as the abnormal development of the reproductive system,decrease of testosterone level,decline of sperm quality,and impact on the health of offspring,while its regulatory mechanism is far from being clarified.This paper expounds the influence of obesity on the male reproductive system in the aspects of population epidemiology and animal experiments,presents an overview on the action mechanisms of obesity from the perspectives of the hypothalamus-pituitary-testis axis,blood-testis barrier,inflammatory reaction,oxidative stress,testicular germ cell apoptosis,and impact of paternal obesity on the health of offspring,aiming to shed some light on the clinical treatment and prevention of obesity-related male reproductive dysfunction.

关 键 词：肥胖 雄性生殖 睾丸 睾酮 精子 

分 类 号：R589.2[医药卫生—内分泌] R698.2[医药卫生—内科学]