硬脑膜修复材料制备及应用研究进展  

Advances in the Preparation and Application of Dural Repair Materials

作　　者：高觊兴 丁玉梅[1] 杨涛[3] 李好义[1,2] 杨卫民[1,2] 张超[1,2] Jixing Gao;Yumei Ding;Tao Yang;Haoyi Li;Weimin Yang;Chao Zhang(Beijing Laboratory of Biomedical Materials,Beijing University of Chemical Technology,Beijing 100029,China;School of Mechanical and Electrical Engineering,Beijing University of Chemical Technology,Beijing 100029,China;China Chemical Fiber Industry Association,Beijing 100022,China)

机构地区：[1]北京化工大学生物医用材料北京实验室,北京100029 [2]北京化工大学机电工程学院,北京100029 [3]中国化学纤维工业协会,北京100022

出　　处：《高分子材料科学与工程》2025年第2期153-161,共9页Polymer Materials Science & Engineering

基　　金：国家重点研发计划(2022YFB3804204);中国石化总部科技部项目(222014)。

摘　　要：在30%的颅脑手术中,神经外科医生需要修复硬脑膜,硬脑膜修复材料对维持脑组织完整和保护脑组织具有重要作用。文中对硬脑膜的概念进行了介绍,针对硬脑膜修复所使用的自体组织、同种异体组织、异种来源组织和人工合成材料的优缺点进行了阐述,并对硬脑膜修复材料的制备方法进行了总结,最后展望了未来人工硬脑膜修复材料的发展方向,指出熔体静电纺纤维膜材料在硬脑膜修复领域具有巨大的应用潜力。In 30%of craniofacial surgeries,neurosurgeons need to repair the dura mater,and dura repair materials play an important role in maintaining the integrity and protection of brain tissue.In this paper,the concept of dura mater was introduced,the advantages and disadvantages of autologous tissues,allogeneic tissues,tissues of heterologous origin and synthetic materials used for dura mater repair were elaborated,the preparation methods of dura mater repair materials were summarized,and finally,the future development direction of artificial dura mater repair materials was looked forward to,and it was pointed out that melt electrostatically spun fiber membrane materials have great application in the field of dura mater repair.

关 键 词：人工硬脑膜 修复材料 静电纺丝 组织工程 

分 类 号：R318.08[医药卫生—生物医学工程]