杭州地区体检健康人群血脂水平调查  

Investigation and analysis of blood lipid levels in population of health check-up in Hangzhou

作　　者：蒋孝娟 范利娜 杨大干 JIANG Xiaojuan;FAN Lin;YANG Dagan(College of Medical Technology and Information Engineering School,Zhejiang Chinese Medical University,Hangzhou 310053;Department of Laboratory Science,The First People's Hospital of Yuhang District,Hangzhou 311113;Department of Laboratory Medicine,The First Afiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,Zhejiang,China)

机构地区：[1]浙江中医药大学医学技术与信息工程学院,杭州310053 [2]杭州市余杭区第一人民医院检验科,杭州311113 [3]浙江大学医学院附属第一医院检验科,杭州310003

出　　处：《临床检验杂志》2025年第4期296-299,共4页Chinese Journal of Clinical Laboratory Science

基　　金：国家重点研发计划(2022YFC3602302)。

摘　　要：目的利用体检大数据调查杭州地区体检健康人群的血脂水平,为疾病预防提供参考。方法收集2022年1月至2023年10月浙江大学医学院附属第一医院体检人群的血脂结果,排除体检阳性指标结果。用SPSS25.0计算按性别和年龄10岁分组的中位数(第25百分位数,第75百分位数)[M(P_(25),P_(75))],用TMC计算第2.5百分位数(P_(2.5))和第97.5百分位数(P_(97.5)),用GAMLSS绘制年龄连续百分位数图。结果血脂水平存在性别差别,对于总胆固醇(TC)、三酰甘油(TG)和低密度脂蛋白胆固醇(LDL-C),在19~49岁各组男性高于女性;对于TC和LDL-C,在50~90岁各组女性高于男性;对于TG,在60~90岁各组女性高于男性,而高密度脂蛋白胆固醇(HDL-C)是女性高于男性。TC男性在40~49岁达到最高点,而女性在70~79岁达到最高点。LDL-C男性在40~49岁达到峰值,而女性在60~69岁达到峰值。血脂水平与年龄相关,其中TG、女性TC和女性LDL-C变化特别显著,随年龄增大先升后降。结论血脂水平与性别和年龄密切相关,应结合性别、年龄等进行个性化的血脂管理。Objective To investigate the blood lipid levels in the population undergoing physical check-up population in Hangzhou district using the laboratory Big Data for providing references in disease prevention.Methods The test results of blood lipid levels of the individuals undergoing health check-up at a certain hospital from January 2022 to October 2023 were collected,excluding the abnormal positive resultss.SPSS 25.0 software was used to calculate the median(M),25th percentile(P_(25))and 75 Percentile(P_(75))grouped by gender and age in 10-year intervals.TMC was used to calculate 2.5th percentile(P_(2.5))and 97.5th percentile(P_(97.5)),and GAMLSS was used to draw the age-continuous percentile charts.Results Gender differences in blood lipid levels were observed.The levels of total cholesterol(TC),triglycerides(TG),and low-density lipoprotein cholesterol(LDL-C)in males were higher than those of females in the age of 19 to 49 groups.However,the levels of TC and LDL-C in females were higher than those of males in the age of 50 to 90 groups.TG levels in females were higher than those of males in the age of 60 to 90 groups.High-density lipoprotein cholesterol(HDL-C)levels in females were higher than those in males.TG level in males at ages of 40 to 49 reached peak,while females reached the peak of TG level at ages of 70 to 79.The LDL-C level in males at ages 40 to 49 reached the peak,while females reached the peak of LDL-C level at ages 60 to 69.Blood lipid levels were associated with age.The levels of TG,TC in female and LDL-C in female showed particularly significant changes,first increasing and then decreasing with age.Conclusion Blood lipid levels are closely related to gender and age.Personalized lipid management should be conducted,considering the factors of gender and age.

关 键 词：大数据 血脂 参考区间 临床决策 

分 类 号：R446[医药卫生—诊断学]