全球儿科呼吸联盟倡议:使用预防性单克隆抗体保护所有婴儿免受呼吸道合胞病毒严重感染  

Global Pediatric Pulmonology Alliance initiative: to protect all infants against respiratory syncytial virus with prophylactic monoclonal antibodies

作　　者：全球儿科呼吸联盟 中国医药教育协会儿科专业委员会 中华医学会儿科学分会呼吸学组 中国医师协会呼吸医师分会儿科呼吸工作委员会 中国研究型医院学会儿科学专业委员会 中国非公立医疗机构协会儿科专业委员会 中国中药协会儿童健康与药物研究专业委员会 中国医药新闻信息协会儿童安全用药分会 申昆玲[2,3] 杨永弘 Lance Rodewald[4] 谢正德 徐保平[2] 曹玲[5] 陈祥鹏[2] 邓继岿[3] 方海[6] 符州 李昌崇[8] 李有 卢根 钱渊 秦强[2] 尚云晓[12] 孙丽红[13] 张海邻 张燕 赵林清[11] 郑跃杰[3] Global Pediatric Pulmonology Alliance;China Medicine Education Association Committee on Pediatrics;The Subspecialty Group of Respiratory Diseases,The Society of Pediatrics,Chinese Medical Association;Chinese Medical Doctor Association Committee on Respirology Pediatrics;Chinese Research Hospital Association Committee on Pediatrics;Chinese Non-Government Medical Institutions Association Committee on Pediatrics;China Association of Traditional Chinese Medicine,Committee on Children's Health and Medicine Research;China News of Drug Information Association,Committee on Children's Safety Medication;Shen Kunling;Yang Yonghong;Lance Rodewald(不详;Beijing Children's Hospital,Capital Medical University,China National Clinical Research Center of Respiratory Diseases,National Center for Children's Health,Beijing 100045,China;Shenzhen Children's Hospital,Shenzhen 518038,China;Immunization Planning Center of Chinese Center for Disease Control and Prevention,Beijing,102211,China)

机构地区：[1]不详 [2]国家儿童医学中心,国家呼吸系统疾病临床医学研究中心,首都医科大学附属北京儿童医院,北京100045 [3]深圳市儿童医院,深圳518038 [4]中国疾病预防控制中心免疫规划中心,北京102211 [5]首都儿科研究所附属儿童医院 [6]北京大学中国卫生发展研究中心 [7]国家儿童健康与疾病临床医学研究中心,重庆医科大学附属儿童医院 [8]温州大学附属第二医院/育英儿童医院 [9]南京医科大学公共卫生学院 [10]广州医科大学附属妇女儿童医疗中心 [11]首都儿科研究所 [12]中国医科大学附属盛京医院 [13]广州医科大学附属第一医院 [14]中国疾病预防控制中心病毒病预防控制所

出　　处：《中华实用儿科临床杂志》2025年第4期241-245,共5页Chinese Journal of Applied Clinical Pediatrics

摘　　要：呼吸道合胞病毒(RSV)是婴儿罹患呼吸道感染疾病而住院的首要病毒病原,保护所有婴儿(AIP)免受RSV严重感染已成为全球范围内应对RSV感染的优先策略。真实世界证据表明,预防性应用单克隆抗体(简称单抗)是有效减轻婴儿RSV相关住院负担、落实AIP策略的有效措施。全球儿科呼吸联盟(GPPA)建议所有RSV流行季出生的新生儿和即将进入第1个RSV流行季的婴儿注射预防性单抗以预防RSV引起的下呼吸道感染。在RSV流行具有典型季节性的地区,GPPA还建议按照季节性接种策略部署RSV单抗注射工作,以提高注射覆盖率和可操作性。Respiratory syncytial virus(RSV)is the leading viral pathogen for the hospitalization of infants with respiratory infection,and all-infant protection(AIP)from severe RSV infection has been identified as a major global priority.Real-world evidence has shown that prophylactic monoclonal antibodies(mAbs)represent an avenue for effectively addressing this leading cause of hospitalization of infants.The Global Pediatric Pulmonology Alliance(GPPA)recommends prophylactic mAbs for all infants who are born during or just prior to entering their first RSV season.In settings where RSV seasonality exists,GPPA also advocates for a seasonal offering of prophylactic RSV mAbs to promote high uptake and operational effectiveness.

关 键 词：呼吸道合胞病毒 单克隆抗体 预防 倡议 婴儿 

分 类 号：R725.6[医药卫生—儿科]