正常儿童血清半乳糖基缺陷IgA1及半乳糖基缺陷IgA1/IgA比值特征  

The characteristics of serum galactose-deficient IgA1 and galactose-deficient IgA1/IgA ratio in normal children

作　　者：刘曼 赵青 孙玲 何海秋 徐征 王辉[1,2] 周楠 Liu Man;Zhao Qing;Sun Ling;He Haiqiu;Xu Zheng;Wang Hui;Zhou Nan(Department of Nephrology,Baoding Hospital of Bejing Children's Hospital,Capital Medical University,Baoding 071000,China;Baoding Key Laboratory of Basic and Clinical Pediatric Nephrology,Baoding 071000,China;Clinical Laboratory,Baoding Hospital of Beijing Children's Hospital,Capital Medical University,Baoding 071000,China;Department of Nephrology,Beijing Children's Hospital,Capital Medical University,Regional Center for Children's Health,Beijing 100045,China)

机构地区：[1]首都医科大学附属北京儿童医院保定医院肾脏内科,保定071000 [2]保定市儿童肾脏病基础与临床重点实验室,保定071000 [3]首都医科大学附属北京儿童医院保定医院检验科,保定071000 [4]国家儿童医学中心,首都医科大学附属北京儿童医院肾脏内科,北京100045

出　　处：《中华实用儿科临床杂志》2025年第4期273-276,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：河北省卫生健康委员会医学科研项目(20230255);保定市科技计划项目(社发类医疗卫生)(2141ZF280,2241ZF077)。

摘　　要：目的探讨正常儿童血清半乳糖基缺陷IgA1(Gd-IgA1)及Gd-IgA1/IgA比值水平的规律特征。方法横断面研究。纳入2023年3-8月河北省保定市1所幼儿园及3所中小学的学龄前儿童、小学生及初中生。按照年龄分为3~6岁组,>6~11岁组,>11~16岁组;成人组作为对照组;采用免疫比浊法检测血清IgA,酶联免疫吸法检测Gd-IgA1、Gd-IgA1/IgA水平,并对上述指标进行正态性检验及方差分析或秩和检验。结果共纳入136例正常人群进行分析,其中男64人,女72人。3~6岁组13人,>6~11岁组51人,>11~16岁组56人,体检中心健康成人(28~45岁)对照16人。各组血清IgA水平:3~6岁组(0.88±0.35)g/L,>6~11岁组(1.38±0.65)g/L,>11~16组(1.78±0.61)g/L,成人组(2.49±0.94)g/L,除3~6岁组与>6~11岁组、12~16岁组与成人组差异无统计学意义外,其他年龄组间差异均有统计学意义(均P<0.05)。各组血清Gd-IgA1水平:3~6岁组7.77(5.77,16.51)μg/L,>6~11岁组7.12(5.29,9.82)μg/L,>11~16组8.96(6.21,14.30)μg/L,成人组9.39(6.63,40.00)μg/L,差异有统计学意义(H=9.22,P=0.027)。血Gd-IgA1/IgA比值组间差异无统计学意义(P=0.130)。相关性分析提示,Gd-IgA1/IgA1与年龄无相关性(r=0.134,P=1.200)。Gd-IgA1水平与IgA水平呈正相关(r=0.204,P=0.017)。不同性别组之间,血清IgA、Gd-IgA1、Gd-IgA1/IgA水平的差异均无统计学意义(均P>0.05)。结论儿童不同年龄组间Gd-IgA1水平存在差异,Gd-IgA1/IgA与年龄无相关性。作为生物诊断标志物,Gd-IgA1需关注年龄阶段的差异,Gd-IgA1/IgA似乎更具有优势,便于临床研究和应用。Objective:To explore the characteristics of serum galactose-deficient IgA1(Gd-IgA1)and Gd-IgA1/IgA ratio in normal children.Methods:The children from a kindergarten and 3 primary or secondary schools in Baoding(Hebei Province)from March to August 2023 were included in the cross-sectional study.According to their age,the children were divided into the 3-6-year-old group,>6-11-year-old group,and>11-16-year-old group.Besides,some adults were also included as the control group.The immunoturbidimetric assay was used to detect serum IgA levels,and the enzyme-linked immunosorbent assay(ELISA)was employed to detect Gd-IgA1 and Gd-IgA1/IgA levels.The above indicators were subject to normal distribution tests and analysis of variance(ANOVA)or rank sum test.Results:A total of 136 normal subjects were included for analysis.Among these subjects,there were 64 males and 72 females.There were 13 children in the 3-6-year-old group,51 children in the>6-11-year-old group,and 56 children in the>11-16-year-old group.Besides,16 normal adults(28-45 years old)from the physical examination center were also included as the control group.The serum IgA levels of the 3-6-year-old group,>6-11-year-old group,>11-16-year-old group,and adult group were(0.88±0.35)g/L,(1.38±0.65)g/L,(1.78±0.61)g/L,and(2.49±0.94)g/L,respectively.Except for no statistically significant difference between the 3-6-year-old group and the>6-11-year-old group,as well as between the>11-16-year-old group and the adult group,all other age groups showed statistically significant differences in serum IgA levels(all P<0.05).The serum Gd-IgA1 levels of the 3-6-year-old group,>6-11-year-old group,>11-16-year-old group,and adult group were 7.77(5.77,16.51)μg/L,7.12(5.29,9.82)μg/L,8.96(6.21,14.30)μg/L,and 9.39(6.63,40.00)μg/L,respectively,with statistically significant differences(H=9.22,P=0.027).There was no significant difference in the Gd-IgA1/IgA ratio among different groups(P=0.130).The correlation analysis suggested that Gd-IgA1/IgA1 did not correlate with age(r=0.13

关 键 词：儿童 免疫球蛋白A 半乳糖基缺陷IgA1 

分 类 号：R725.9[医药卫生—儿科]