病毒性心肌炎实验模型的研究进展  

Progress in experimental models of viral myocarditis

作　　者：徐奕 罗震 尤洁瑜 蓝县武 巫少荣 XU Yi;LUO Zhen;YOU Jieyu;LAN Xianwu;WU Shaorong(Cardiology Department,The First Affiliated Hospital of Jinan University,Guangzhou Overseas Chinese Hospital,Guang-zhou 510630,China;College of Life Science and Technology,Jinan University,Guangzhou 510630,China)

机构地区：[1]暨南大学附属第一医院,广州华侨医院心血管内科,广东广州510630 [2]暨南大学生命科学技术学院,广东广州510630

出　　处：《中国病理生理杂志》2025年第4期783-790,共8页Chinese Journal of Pathophysiology

基　　金：广州市科技计划项目(No.2025A03J4225);广州市基础与应用基础项目(No.202201010536);国家自然科学基金青年科学基金项目(No.82300567)。

摘　　要：病毒性心肌炎是一种由各种病毒感染所引起的心肌疾病,由于其发病机理复杂,目前尚缺乏有效的预防和治疗方法,因此建立适合的实验模型对于研究病毒性心肌炎发病机制、发展规律、早期诊断及新药新疗法的开发具有重要意义。本文综述了常见病毒性心肌炎实验模型(从细胞模型到小型动物如小鼠、仓鼠、兔子,再到大型动物如猪和非人灵长类动物等不同种属)的构建方法、研究进展及其在基础研究中的应用,对其今后的研究方向进行了总结和展望,为临床上防治病毒性心肌炎提供理论依据和技术支持。Viral myocarditis is a myocardial disease resulting from various viral infections.Due to the complexity of its pathogenesis,effective prevention and treatment options are currently lacking.Establishing appropriate experimental models is crucial for studying the pathogenic mechanisms,disease progression,early diagnosis,and the development of new drugs and therapies for viral myocarditis.This article reviews the construction methods,research advancements,and applications of common experimental models of viral myocarditis,which range from cell models to small animal models,including mice,hamsters,and rabbits,as well as larger animals such as pigs and non-human primates.Additionally,we summarize and discuss future research directions,providing a theoretical foundation and technological guidance for the prevention and treatment of viral myocarditis in clinical settings.

关 键 词：病毒性心肌炎 实验模型 动物模型 模型应用 

分 类 号：R542.21[医药卫生—心血管疾病] R965.1[医药卫生—内科学] R363[医药卫生—临床医学]