GC法测定头孢哌酮酸中N,N-二甲基乙酰胺的残留  

A GC Method for Determination of DMA Content in Cefoperazone Acid

作　　者：马苏杰 赵玉娟 张立斌 李敏 陈可涛 张建丽 MA Su-jie;ZHAO Yu-juan;ZHANG Li-bin;LI Min;CHEN Ke-tao;ZHANG Jian-li(NCPC Hebei Huamin Pharmaceutical Co.,Ltd.,Shijiazhuang 052165,China;Hebei Province Cephalosporide Medicine Preparation Technology,Shijiazhuang 052165,China;National and Local Joint Engineering Laboratory of Antibiotic Enzyme Catalysis and Crystallization Technology,Shijiazhuang 052165,China;Hebei Province Company Technology Center,Shijiazhuang 052165,China;Shijiazhuang Company Technology Center,Shijiazhuang 052165,China)

机构地区：[1]华北制药河北华民药业有限责任公司,河北石家庄052165 [2]河北省头孢类药物制备技术创新中心,河北石家庄052165 [3]抗生素酶催化与结晶技术国家地方联合工程实验室,河北石家庄052165 [4]河北省企业技术中心,河北石家庄052165 [5]石家庄市企业技术中心,河北石家庄052165

出　　处：《精细化工中间体》2025年第2期81-84,88,共5页Fine Chemical Intermediates

摘　　要：建立了气相色谱法(GC)测定头孢哌酮酸中N,N-二甲基乙酰胺(DMA)残留量的分析方法。采用FID检测器,以DB-WAX毛细管柱为色谱柱。经过验证,DMA在4.4576~133.7280μg/mL范围内线性关系良好(r=0.9992)。该方法专属性良好,操作简单,重复性好,可为头孢类品种检测DMA残留提供试验依据。A GC method is estabished for the content determination of DMA in cefoperazone acid.The FID detector is employed,with the DB-WAX capillary column used as the chromatographic column.The linearity of calibration curve for DMA is good in the range of 4.4576~133.7280μg/mL(r=0.9992).The established method is simple,specific and has good repeatability,and can be used to determine the residual content of DMA for the cephalosporin products.

关 键 词：色谱分析 气相色谱法 头孢类产品 头孢哌酮酸 N N-二甲基乙酰胺 残留量 

分 类 号：TQ465.91[化学工程—制药化工]