基于细胞自噬与凋亡探讨腰椎间盘突出重吸收的研究进展  

Advances in the study of lumbar disc herniation resorption based on cellular autophagy and apoptosis

作　　者：陶瑜晶 孙凤歧[2] 陈伟国 赵恒 张万乾 郑刚 谢芋涛 任毅 杨建霞 TAO Yujing;SUN Fengqi;CHEN Weiguo;ZHAO Heng;ZHANG Wanqian;ZHENG Gang;XIE Yutao;REN Yi;YANG Jianxia(Clinical School of Traditional Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730030;Department of Minimally Invasive Spine Orthopedics,Gansu Hospital of Traditional Chinese Medicine,Lanzhou 730050)

机构地区：[1]甘肃中医药大学中医临床学院,兰州730030 [2]甘肃省中医院脊柱微创骨科,兰州730050

出　　处：《颈腰痛杂志》2025年第2期383-387,共5页The Journal of Cervicodynia and Lumbodynia

基　　金：甘肃省自然科学基金项目(22JR5RA623)。

摘　　要：腰椎间盘突出症(LDH)是临床常见的一种脊柱疾病,如何通过非手术治疗达到临床预期的效果,这一直是医学领域的研究热点。临床上发现部分患者通过腰椎间盘突出重吸收的发生而缓解了症状。细胞自噬与凋亡作为两种重要的细胞死亡方式,在腰椎间盘突出重吸收的研究中有着重要意义。本文综述了细胞自噬和凋亡在腰椎间盘突出重吸收中的作用,并探讨了二者的相互作用,以及在未来潜在的应用价值,希望为未来寻求新的治疗策略提供部分理论依据。Lumbar disc herniation(LDH)is a common clinical spinal disease,and it has been a hot research topic in the medical field how to achieve the clinically expected results through non-surgical treatment.Clinical relief in some patients through the occurrence of resorption of lumbar disc herniation.Cell autophagy and apoptosis,as two important modes of cell death,are of great significance in the study of resorption of lumbar disc herniation.In this paper,the roles of cell autophagy and apoptosis in the resorption of lumbar disc herniation are reviewed,and the interactions between the two are discussed,as well as their potential application value in the future,hoping to provide a partial theoretical basis for the search of new therapeutic strategies in the future.

关 键 词：细胞自噬 细胞凋亡 腰椎间盘突出 重吸收 

分 类 号：R681.57[医药卫生—骨科学]