医用聚醚砜多孔膜制备及改性研究进展  

Development of porous membrane preparation and modification of medical polyethersulfone

作　　者：陈佳桐 奚振宇[1] 谢松辰 张新妙[1] CHEN Jiatong;XI Zhenyu;XIE Songchen;ZHANG Xinmiao(Sinopec(Beijing)Research Institute of Chemical Industry Co.,Ltd.,Beijing 100013,China)

机构地区：[1]中石化(北京)化工研究院有限公司,北京100013

出　　处：《膜科学与技术》2025年第2期184-191,共8页Membrane Science and Technology

基　　金：国家自然基金项目(U22B6012);中国石化科技开发项目(222100)。

摘　　要：医用聚醚砜(PES)膜因其优异的机械强度、耐化学性和生物相容性,广泛应用于血液透析、药物过滤等领域。然而,不同应用对膜的结构、孔径和性能有着不同的要求,因此需要采用不同的相分离法来制备特定用途的PES膜。本文综述了几种主要的相分离方法,包括非溶剂致相分离法、蒸汽诱导相分离法及逆向热致相分离法,并对其制备的膜结构、渗透通量及性能进行了系统比较。此外,本文还关注了适用于医用PES膜的亲水性和生物相容性改性方法,涵盖了本体改性和表面改性两种主要策略,评估了它们在实际医用膜领域中的应用可行性及优缺点。Medical polyethersulfone(PES)membranes,due to their excellent mechanical strength,chemical resistance,and biocompatibility,are widely used in fields such as hemodialysis and drug filtration.However,different applications require membranes with different structures,pore sizes,and performance characteristics.Therefore,multiple phase separation methods are needed to fabricate PES membranes tailored for specific uses.This paper reviews several major phase separation methods,including non-solvent induced phase separation(NIPS),vapor induced phase separation(VIPS),and reverse thermally induced phase separation(RTIPS),and systematically compares the membrane structures,permeation fluxes,and performances produced by these methods.In addition,this paper focuses on hydrophilic and biocompatibility modification methods for medical PES membranes,covering two main strategies:bulk modification and surface modification.The feasibility and advantages and disadvantages of these methods in practical medical membrane applications are also evaluated.

关 键 词：聚醚砜 医用膜 相分离法 亲水改性 

分 类 号：R318.08[医药卫生—生物医学工程] TQ051.893[医药卫生—基础医学]