一种通过对菌种发酵工艺改进来提高鸟苷产量的方法  

A Method to Increase Guanosine Production by Improving the Fermentation Process of Bacterial Strains

作　　者：王海波 WANG Haibo

机构地区：[1]广东肇庆星湖生物科技股份有限公司,广东肇庆526040

出　　处：《化工设计通讯》2025年第4期13-15,共3页Chemical Engineering Design Communications

摘　　要：发酵过程中采用利用率较高的有机氮源替代普通氮源,在发酵前期补入部分补糖,改善了发酵前期溶氧偏低的现象。最终使得发酵液中的鸟苷含量由61 g/L提高至70 g/L,转化率23%以上,为产业化提供有力参考。During the fermentation process,organic nitrogen sources with higher-utilization are used instead of ordinary nitrogen sources.Partial sugar supplementation is added in the early stage of fermentation to improve the phenomenon of low dissolved oxygen in the early stage of fermentation.Ultimately,the content of guanosine in the fermentation can be increased from 61 g/L to 70 g/L,with a conversion rate of over 23%,providing strong reference for industrialization.

关 键 词：鸟苷 前期补糖 高核酸酵母 

分 类 号：Q815[生物学—生物工程]