岗藿清瘟颗粒治疗风热夹湿证流行性感冒的临床疗效研究  

Study on the clinical efficacy of Ganghuo Qingwen Granule(岗藿清瘟颗粒)in treating influenza with wind-heat complicated with dampness syndrome

作　　者：吴文玉 方煜民 蓝婉宁 吴鹏 王凯 廖钢 江勇 彭晓芸 温武金 詹少锋[1,2] WU Wen-yu;FANG Yu-min;LAN Wan-ning;WU Peng;WANG Kai;LIAO Gang;JIANG Yong;PENG Xiao-yun;WEN Wu-jin;ZHAN Shao-feng(School of the First Clinical Medicine of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;First Afiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Afiliated Hospital of Nanjing University of Chinese Medicine/Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China;Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine,Shenzhen 518033,China)

机构地区：[1]广州中医药大学第一临床医学院,广东广州510405 [2]广州中医药大学第一附属医院,广东广州州510405 [3]南京中医药大学附属医院,江苏省中医院,江苏南京210029 [4]深圳市中西医结合医院,广东深圳1518033

出　　处：《时珍国医国药》2025年第6期1093-1097,共5页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(81973814,82474409);广东省中医药科研项目(20231169,20231344,20251124);广东省自然科学基金(2024A1515012160);深圳市宝安区医学会医疗卫生科研项目(BAYXH2024011);国家中医药传承创新中心科研专项项目(2022QN24,2022QN27);广东省医学科学技术研究基金项目(B2023051)。

摘　　要：目的观察岗藿清瘟颗粒治疗风热夹湿证流行性感冒的临床疗效。方法选取广州中医药大学第一附属医院及深圳市中西医结合医院流感患者84例,随机分为对照组和治疗组,除去4个脱落病例,试验组和治疗组分别完成40例,试验组给予岗藿清瘟颗粒治疗,对照组给予磷酸奥司他韦胶囊治疗,体温超过38.5℃时,予对乙酰氨基酚片并记录用量,在治疗第3天时,比较两组的临床疗效、完全退热时间、使用对乙酰氨基酚情况及不良反应发生情况。结果试验组在临床疗效、完全退热时间优于对照组,两组在使用对乙酰氨基酚片及不良反应发生情况方面没有统计学差异。结论岗藿清瘟颗粒可有效缓解流感症状,在一定程度上可降低重症流感的风险,为进一步推广岗藿清瘟颗粒的应用与研究奠定了基础,未来需更多更大的随机、平行、对照、双盲、多中心临床试验以进一步验证岗藿清瘟颗粒在流感领域应用的安全性和有效性。Objective To observe the clinical efficacy of Ganghuo Qingwen Granule(岗藿清瘟颗粒,GHQWG)in treating influenza with wind-heat complicated with dampness syndrome.Methods A total of 84 influenza patients from the First Affiliated Hospital of Guangzhou University of Chinese Medicine and Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine were randomly divided into the control group and the treatment group.After excluding 4 dropout cases,40 cases were completed in each group.The treatment group received GHQWG,while the control group received Oseltamivir phosphate capsules.Acetaminophen tablets were administered and their dosage recorded for patients with a body temperature exceeding 38.5°C.Clinical efficacy,complete fever resolution time,use of acetaminophen,and adverse reactions were compared between the two groups at the 3rd day of treatment.Results The treatment group demonstrated better performance in clinical efficacy and complete fever resolution time than in the control group.There was no statistical difference between the two groups in acetaminophen tablets usage or occurrence of adverse reactions.Conclusion GHQWG can effectively alleviate influenza symptoms and reduce the risk of severe influenza to a certain extent.This study lays a foundation for further promotion of the application and research of GHQWG.Future large-scale randomized,parallel,controlled,double-blind,multicenter clinical trials are required to further validate the safety and efficacy of GHQWG in influenza treatment.

关 键 词：岗藿清瘟颗粒 流行性感冒 风热夹湿证 

分 类 号：R254.9[医药卫生—中医内科学]