中药单体抑制NLRP3炎症小体治疗哮喘的研究进展  

Research progress on Chinese herbal medicine monomers in the treatment of asthma by inhibiting NLRP3 inflammasome

作　　者：彭果然 程贝贝 丁蓉珍 戴爱国 PENG Guo-ran;CHENG Bei-bei;DING Rong-zhen;DAI Ai-guo(School of Integrated Chinese and Western Medicine of Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Key Laboratory of Vascular Biology and Translational Medicine,Changsha 410208,China;Research Laboratory of Respiratory Diseases,School of Medicine of Hunan University of Chinese Medicine,Changsha 410208,China;First Afiliated Hospital of Hunan University of Chinese Medicine,Changsha 410021,China)

机构地区：[1]湖南中医药大学中西医结合学院,湖南长沙410208 [2]血管生物学与转化医学湖南省重点实验室,湖南长沙410208 [3]湖南中医药大学医学院呼吸疾病研究室,湖南长沙410208 [4]湖南中医药大学第一附属医院,湖南长沙少410021

出　　处：《时珍国医国药》2025年第6期1134-1140,共7页Lishizhen Medicine and Materia Medica Research

基　　金：湖南省教育厅科学研究项目(22B0383);湖南省研究生科研创新项目(CX20230819);湖南中医药大学校级研究生创新课题(2023CX117);湖南中医药大学-湖南明康中锦医疗科技发展有限公司联合基金项目(2022MKZJ08);长沙市自然科学基金(kq2208184)。

摘　　要：哮喘是一种常见的慢性炎症性气道疾病,其发病机制复杂。核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体是一种触发炎症反应的蛋白质复合物,参与细胞焦亡的调控过程,在哮喘的发病机制中发挥着重要作用。文章综述了NLRP3炎症小体的组成、功能,与细胞焦亡的关系及其在哮喘发病机制中的作用,并探讨了中药单体抑制NLRP3炎症小体治疗哮喘的研究进展,为未来的研究和临床应用提供参考。Asthma is a common chronic inflammatory airway disease with a complex pathogenesis.The nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome is a protein complex that triggers inflammatory responses,participating in the regulation of pyroptosis and playing a significant role in the pathogenesis of asthma.This article reviews the composition and function of the NLRP3 inflammasome,its relationship with pyroptosis,and its role in asthmatic pathogenesis.Additionally,it explores recent advances in the use of Chinese herbal medicine(CHM)monomers to inhibit the NLRP3 inflammasome for treating asthma,offering insights for future research and clinical applications.

关 键 词：中药单体 NLRP3炎症小体 哮喘 细胞焦亡 

分 类 号：R256.12[医药卫生—中医内科学]