机构地区:[1]新疆医科大学第五附属医院全科医学科,新疆乌鲁木齐830011 [2]新疆医科大学第五附属医院心血管内科,新疆乌鲁木齐830011
出 处:《社区医学杂志》2025年第3期90-95,共6页Journal Of Community Medicine
基 金:国家自然科学基金项目(81960073);“天山英才”医药卫生高层次人才培养计划(TSYC202301B015);新疆医科大学2024年研究生创新项目(CXCY2024013);新疆医科大学2024年研究生创新项目(XJ2024G165)。
摘 要:目的探讨早期生长反应因子3(Egr3)和系统炎症反应指数(SIRI)与冠状动脉粥样硬化严重程度的相关性及其在冠状动脉粥样硬化性心脏病(简称冠心病)中的联合诊断价值。方法选取于新疆医科大学第五附属医院2021-06-01-2021-12-31入院并完善冠状动脉造影检查者共169人。将冠脉造影检查结果正常者(59名)作为对照组,并将诊断为冠心病的患者依据Gensini评分分为轻度狭窄组(≤24分,55例)和中重度狭窄组(>24分,55例)。采用酶联免疫吸附法(ELISA)检测各组患者的血清Egr3水平,比较各组组间资料的差异性,采用有序logistic回归分析影响冠状动脉粥样硬化严重程度的因素。绘制受试者工作特征(ROC)曲线,评价各指标在冠心病中的单独检测及联合检测价值。结果中重度狭窄组Egr3值为2229.06(1382.13,3038.54)ng/L,高于轻度狭窄组的1290.30(1031.10,1835.07)ng/L,高于对照组的913.98(717.44,1449.07)ng/L,差异有统计学意义,均P<0.05,且轻度狭窄组Egr3值高于对照组,差异有统计学意义,P<0.05;3组Egr3值相比较,差异有统计学意义,P<0.05;中重度狭窄组SIRI值为14.3(10.6,21.7)×10^(8)L^(-1),高于轻度狭窄组的9.5(6.9,17.0)×10^(8)L^(-1),高于对照组的7.1(4.9,10.9)×10^(8)L^(-1),差异有统计学意义,均P<0.05,且轻度狭窄组Egr3值高于对照组,差异有统计学意义,P<0.05;3组SIRI值相比较,差异有统计学意义,P<0.05;有序logistic回归分析显示,SIRI值(OR=1.104,95%CI为0.051~0.147,P<0.05)、Egr3值(OR=1.001,95%CI为0.000~0.001,P<0.05)与冠状动脉粥样硬化严重程度呈正相关,是冠状动脉粥样硬化进展的独立危险因素。ROC曲线分析结果表明,SIRI值和Egr3值对冠心病患者诊断的ROC曲线下方的面积(AUC)分别为0.747和0.718,两者联合诊断的AUC为0.768,其诊断效能高于各指标单独检测。结论血浆SIRI和Egr3水平高低和冠状动脉狭窄程度呈正相关,二者均可用于冠心病的早期诊断,二者联合诊断效能�Objective To explore the correlation between early growth response factor 3(Egr3) and systemic inflammatory response index(SIRI) and the severity of coronary atherosclerosis,as well as their combined diagnostic value in coronary atherosclerotic heart disease.Methods A total of 169 patients who underwent coronary angiography at the Fifth Affiliated Hospital of Xinjiang Medical University from June 1,2021to December 31,2021were recruited.Patients with normal coronary angiography results(59 cases) were assigned to the control group,and those diagnosed with CHD were classified into the mild stenosis group(≤24 points,55 cases) and the moderate to severe stenosis group(>24 points,55 cases) based on the Gensini score.The serum Egr3 levels of each group were detected by enzyme-linked immunosorbent assay(ELISA),and the differences in data among the groups were compared.Ordered logistic regression was employed to analyze the factors influencing the severity of coronary atherosclerosis.Receiver operating characteristic(ROC) curves were plotted to evaluate the individual and combined diagnostic value of each index in CHD.Results The Egr3 value in the moderate to severe stenosis group was 2 229.06(1 382.13,3 038.54) ng/L,which was higher than that in the mild stenosis group 1 290.30(1 031.10,1 835.07) ng/L and the control group 913.98(717.44,1 449.07) ng/L,with statistically significant differences(all P<0.05).The Egr3 value in the mild stenosis group was also higher than that in the control group,with a statistically significant difference(P<0.05).There was a statistically significant difference in Egr3values among the three groups(P<0.05).The SIRI value in the moderate to severe stenosis group was 14.3(10.6,21.7)×10^(8)L^(-1),which was higher than that in the mild stenosis group 9.5(6.9,17.0)×10^(8)L^(-1) and the control group7.1(4.9,10.9)×10^(8)L^(-1),with statistically significant differences(all P<0.05).The SIRI value in the mild stenosis group was also higher than that in the control group, with a statistically sig
关 键 词:冠状动脉粥样硬化性心脏病 GENSINI评分 早期生长反应因子3 系统炎症反应指数
分 类 号:R541.4[医药卫生—心血管疾病]
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