中药有效成分及方剂干预胰腺星状细胞治疗慢性胰腺炎的作用机制  

The mechanism of effective traditional Chinese medicine components and prescriptions in treatment of chronic pancreatitis by intervening against pancreatic stellate cells

作　　者：程汝阳 宋蔚宁 蒋鑫 王业豪 刘林 卢芳[2] 刘树民[2] CHENG Ruyang;SONG Weining;JIANG Xin;WANG Yehao;LIU Lin;LU Fang;LIU Shumin(Graduate School,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Institute of Traditional Chinese Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学中医药研究院,哈尔滨150040

出　　处：《临床肝胆病杂志》2025年第4期793-800,共8页Journal of Clinical Hepatology

基　　金：黑龙江省省属本科高校中央支持地方高校改革发展资金人才培养项目(2021ZYQGLG001);黑龙江中医药大学优秀创新人才支持计划项目(2018RCL13)。

摘　　要：慢性胰腺炎(CP)是一种以炎症反复发作和胰腺组织受到进行性损伤为特征的慢性疾病,其病情恶化时还会增加CP患者胰腺癌的发生风险,严重威胁着CP患者的身体健康。近些年,CP发病机制的研究多集中在胰腺星状细胞(PSC)的激活及在胰腺纤维化中的作用。本文详细叙述了PSC在CP中的作用机制,总结了中药有效成分及方剂干预PSC治疗CP的研究现状,指出了中药有效成分及方剂治疗CP的研究方向,为日后CP患者的临床治疗提供参考。Chronic pancreatitis(CP)is a chronic disease characterized by recurrent inflammation and progressive damage to pancreatic tissue,and its deterioration may increase the risk of pancreatic cancer in patients with CP,which seriously threatens the health of patients with CP.In recent years,studies on the pathogenesis of CP have mostly focused on the activation of pancreatic stellate cells(PSCs)and its role in pancreatic fibrosis.This article elaborates on the mechanism of action of PSCs in CP,summarizes the current status of research on effective traditional Chinese medicine components and prescriptions for intervention of PSCs in the treatment of chronic CP,and proposes the future research directions for effective traditional Chinese medicine components and prescriptions,so as to provide a reference for the clinical treatment of CP patients in the future.

关 键 词：胰腺炎 慢性 中药 胰腺星状细胞 

分 类 号：R259[医药卫生—中西医结合]