酰基自由基化学在天然产物全合成中的应用  

Application of Acyl Radical in Total Synthesis of Natural Products

作　　者：谢应 付绍敏 刘波[2] Ying Xie;Shaomin Fu;Bo Liu(School of Chemistry and Environmental Engineering,Sichuan University of Science&Engineering,Zigong,Sichuan 643000;Key Laboratory of Green Chemistry&Technology of Ministry of Education,College of Chemistry,Sichuan University,Chengdu,610064)

机构地区：[1]四川轻化工大学化学与环境工程学院,四川自贡643000 [2]四川大学化学学院绿色化学与技术教育部重点实验室,成都610064

出　　处：《有机化学》2025年第3期852-865,共14页Chinese Journal of Organic Chemistry

基　　金：基金资助:国家自然科学基金(21925106);国家自然科学基金(21921002)。

摘　　要：酰基自由基具有独特的结构特征和高反应活性, 受到有机合成化学家的广泛关注. 近年来, 随着其来源和引发方式的不断创新, 酰基自由基在各种化学转化中的应用日益广泛;特别是在天然产物合成后期的关键步骤中, 酰基自由基因的较小位阻以及不易发生金属介导的β-消除反应等优势, 成为兼容多种官能团行之有效的策略之一. 此文综述了近年来通过酰基自由基化学作为关键步骤在复杂天然产物合成中的应用.Acyl radicals have received extensive attention from organic synthetic chemists due to their unique structural features and high reactivity. In recent years, with the continuous innovation of their acyl sources and initiation modes, acyl radicals have been widely used in various chemical transformations. Especially in the critical step of the late stage of natural product synthesis, acyl radicals have become one of the effective and important strategies compatible with a wide range of functional groups due to the advantages of their smaller site resistance and less susceptibility to metal-mediated β-elimination reactions. Application of acyl radicals as a key step in the synthesis of natural products is summarized.

关 键 词：酰基自由基 天然产物 全合成 自由基环化 

分 类 号：O621.3[理学—有机化学]