Cephalotanin B中螺旋桨型双内酯环系的仿生构建研究  

Research on the Biomimetic Construction of Propeller-Shaped Dual Lactone Ring System in Cephalotanin B

作　　者：孙泽众 金双 王云侠[1] 胡向东[1] Zezhong Sun;Shuang Jin;Yunxia Wang;Xiangdong Hu(Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education,College of Chemistry&Materials Science,Northwest University,Xi'an 710127)

机构地区：[1]西北大学化学与材料科学学院合成与天然功能分子教育部重点实验室,西安710127

出　　处：《有机化学》2025年第3期996-1002,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(21772153);国家自然科学基金(22071192);陕西省基础科学(化学、生物学)研究项目(23JHZ003);陕西省科技厅基金(2019JM-151)。

摘　　要：作为三尖杉二萜家族的一员, cephalotanin B复杂的分子结构拥有一个颇为独特的螺旋桨型双内酯环系. 基于已知生物合成路径的推测, 先后探索了两种仿生构建方案, 开发出了一种新颖的环氧开环/消除/双内酯化串联过程, 最终为cephalotanin B独特的螺旋桨型双内酯环系成功发展出一种简单高效的仿生构建策略.As a member of the family of Cephalotaxus diterpenoids, cephalotanin B possesses a quite unique propeller-shaped dual lactone ring system. Based on known proposal of biosynthetic pathway, two biomimetic construction approaches were explored successively, a novel epoxide-opening/elimination/dual lactonization cascade was exploited, and a brief and efficient biomimetic construction strategy for the unique propeller-shaped dual lactone ring system was developed successfully in the end.

关 键 词：天然产物 复杂结构 仿生合成 

分 类 号：O621.3[理学—有机化学]