基于碳氢键断裂的金属催化的内烯烃不对称氢芳基化进展  

Recent Progress in Metal-Catalyzed Asymmetric Hydroarylation of Internal Alkenes Through C—H Cleavage

作　　者：林恩泽 李必杰 Enze Lin;Bijie Li(Center of Basic Molecular Science,Department of Chemistry,Tsinghua University,Beijing 100084)

机构地区：[1]清华大学化学系基础分子科学中心,北京100084

出　　处：《有机化学》2025年第2期546-558,共13页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.22371160)资助项目。

摘　　要：芳基碳氢键对烯烃的不对称加成是构建苄基手性中心的有效方法,具有原料简单易得、原子经济性高、产物结构多样等优点.芳基碳氢键对端位烯烃的加成研究较早,取得了较大进展.相较而言,芳基碳氢键对内烯烃的不对称加成研究较为滞后.此文将简要综述金属催化的芳基碳氢键对内烯烃不对称加成的近期进展.Catalytic asymmetric addition of aryl C—H bonds to alkenes is an effective method for constructing benzylic chiral centers,offering advantages such as readily available starting materials,high atom economy,and diverse product structures.The study of the addition of aryl C—H bonds to terminal alkenes began earlier and has made significant progress.In contrast,research on the asymmetric addition of aryl C—H bonds to internal alkenes has been relatively lagging behind.The recent advances in metal-catalyzed asymmetric addition of aryl C—H bonds to internal alkenes are reviewed.

关 键 词：碳氢键 内烯烃 氢芳基化 不对称催化 苄基手性中心 

分 类 号：O643.3[理学—物理化学]