选择性C—H键氯化反应进展  

Recent Progress in Selective C—H Chlorination

作　　者：王娟娟 史妍 田英贤 刘丙贤 Juanjuan Wang;Yan Shi;Yingxian Tian;Bingxian Liu(Pingyuan Laboratory,State Key Laboratory of Antiviral Drugs,School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan 453007)

机构地区：[1]河南师范大学化学化工学院抗病毒性传染病创新药物全国重点实验室平原实验室,河南新乡453007

出　　处：《有机化学》2025年第2期574-591,共18页Chinese Journal of Organic Chemistry

基　　金：河南省自然科学基金(Nos.222300420056,222300420204)资助项目。

摘　　要：由于有机氯化物在药物化学、材料化学以及合成化学领域的重要作用,碳氯键的构建一直是有机化学方向热点研究领域.由于通过碳氢键断裂并直接转化为目标官能团具有高度的原子经济性,其被认为是新一代极具潜力的物质构建和转化途径.近年来,随着碳氢键活化转化研究的发展,一些C—H键氯化反应已被开发为传统卤化方法的实用替代方案,此综述对近十年C—H键氯化反应的发展进行了归纳总结.The importance of organic chlorides in pharmaceutical, material, and synthetic chemistry has made the constru- ction of C—Cl bonds a significant focus in organic chemistry. The cleavage and functionalization of C—H bonds with high atomic efficiency, leading to direct conversion into desired functional groups, is seen as a promising approach for creating new substances. Recent advancements in C—H bond activation/tranformation have led to the development of C—H chlorination reactions as viable alternatives to traditional halogenation methods. This review provides an overview of the progress made in C—H bond chlorination reactions over the last decade.

关 键 词：氯化 C—H键 选择性 极性反转 

分 类 号：O621.25[理学—有机化学]