可见光介导的羰基α位C—H官能团化反应合成萘咪酮类衍生物  

Synthesis of Nafimidone Derivatives by Visible-Light-Induced α-C—H Functionalization of Carbonyl

作　　者：沈佳斌 沈超 章鹏飞[3] Jiabin Shen;Chao Shen;Pengfei Zhang(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072;College of Biology and Environmental Engineering,Zhejiang Shuren University,Hangzhou 310015;College of Materials,Chemistry and Chemical Engineering,Hangzhou Normal University,Hangzhou 311121)

机构地区：[1]天津大学化工学院,天津300072 [2]浙江树人学院生物与环境工程学院,杭州310015 [3]杭州师范大学材料与化学化工学院,杭州311121

出　　处：《有机化学》2025年第2期677-685,共9页Chinese Journal of Organic Chemistry

基　　金：浙江省科技厅重点研发计划(No.2024C01203)资助项目。

摘　　要：开发了一种以曙红Y (Esoin Y)为光催化剂的可见光诱导的普适和实用的羰基α位C—H官能团化策略.这种温和的转化为制备具有潜在生物活性的萘咪酮类衍生物提供了一种操作简单、底物范围广且高原子经济的高效便捷的方法.机制研究表明该策略涉及自由基反应机制.A universal and practical visible-light-induced α-functionalization of carbonyl compounds is demonstrated using Esoin Y as photocatalyst. This mild transformation provides an efficient and convenient approach for the synthesis of potentially bioactive nafimidone derivatives with operational simplicity, a broad substrate scope and high atom economy. The mechanistic studies reveal that a free radical pathway mechanism is responsible for this transformation.

关 键 词：可见光催化 C—H官能团化 C—S偶联 C—O偶联 

分 类 号：O621.3[理学—有机化学]