细胞因子在糖尿病足发病机制中的作用及相关信号通路的研究进展  

The Role of Cytokines in the Pathogenesis of Diabetic Foot Ulcers and the Research Progress of Related Signal Pathways

作　　者：陈雄林[1,2] 曹小明 张杰 江晨 CHEN Xionglin;CAO Xiaoming;ZHANG Jie;JIANG Chen(School of Basic Medical Sciences,Jiujiang University,Jiujiang 332005,China;Jiangxi Provincial Key Laboratory of Cell Precision Therapy,Jiujiang 332005,China)

机构地区：[1]九江学院基础医学院,九江332005 [2]细胞精准治疗江西省重点实验室,九江332005

出　　处：《中国细胞生物学学报》2025年第4期975-980,共6页Chinese Journal of Cell Biology

基　　金：江西省自然科学基金(批准号:20232BAB206042)资助的课题。

摘　　要：糖尿病足是糖尿病患者常见且严重的并发症,其严重影响患者的生活质量和健康状况。细胞因子作为重要的生物活性分子,与糖尿病足的发展密切相关。该文综述了不同类型的细胞因子在糖尿病足发病过程中的具体作用及相关信号通路的作用机制,通过对现有研究的系统分析,旨在为糖尿病足的干预和治疗提供新的思路与视角,推动该领域的进一步研究与临床应用。Diabetic foot ulcers are a common and serious complication of diabetes patients,which seriously affects the quality of life and health status of patients.Studies have shown that cytokines,as important bioactive molecules,are closely related to the development of diabetic foot ulcers.This article reviews the specific role of different types of cytokines in the pathogenesis of diabetes foot and the mechanism of related signaling pathways.Through systematic analysis of existing research,it aims to provide new ideas and perspectives for the intervention and treatment of diabetes foot,and promote further research and clinical application in this field.

关 键 词：细胞因子 糖尿病足 信号通路 发病机制 治疗靶点 

分 类 号：R587.2[医药卫生—内分泌]