空心微针制造技术研究进展  

Research progress on the manufacturing technology of hollow microneedles

作　　者：周生硕 周华建 杜筱语 于紫烨 许同乐[1] 赵顺 苏培强 张磊安[1] 付广洋(综述) 刘学磊(审校) ZHOU Shengshuo;ZHOU Huajian;DU Xiaoyu;YU Ziye;XU Tongle;ZHAO Shun;SU Peiqiang;ZHANG Leian;FU Guangyang;LIU Xuelei(School of Mechanical Engineering,Shandong University of Technology,Zibo,Shandong 255000,P.R.China;Shandong Huiyu Auto Parts Co.,Ltd.Binzhou,Shandong 251702,P.R.China)

机构地区：[1]山东理工大学机械工程学院,山东淄博255000 [2]山东惠宇汽车零部件有限公司,山东滨州251702

出　　处：《生物医学工程学杂志》2025年第2期423-430,共8页Journal of Biomedical Engineering

基　　金：国家自然科学基金(12302201);山东省自然科学基金(ZR2022QE289)。

摘　　要：空心微针(HMN)给药具有无痛、避免首过效应、可持续输注及无需专业人员操作等优点。此外,HMN还可以被应用于体液提取及生物传感器等领域,因此具有广阔的应用前景。但是,传统的制造技术无法实现HMN低成本大批量生产的需求,从而限制了HMN的普及应用。本文回顾了近年来用于HMN制造的主要技术,包括光刻及刻蚀、激光刻蚀、溅射及电镀、微模塑、三维(3D)打印以及拉延光刻等,并进一步分析了现有制造技术的特点和局限,指出多种制造技术结合使用能够在一定程度上提高生产效率。此外,本文还对HMN制造技术的未来发展趋势进行了展望,提出了HMN制造技术可能的发展方向。总之,期望通过本文综述,可为后续研究提供新的思路及参考。Drug administration via hollow microneedles(HMN) have the advantages of painlessness, avoidance of first-pass effect, capability of sustained infusion, and no need for professional personnel operation. In addition, HMN can also be applied in the fields of body fluid extraction and biosensors, showing broad application prospects. However,traditional manufacturing technologies cannot meet the demand for low-cost mass production of HMN, limiting its widespread application. This paper reviews the main manufacturing technologies used for HMN in recent years, which include photolithography and etching, laser etching, sputtering and electroplating, micro-molding, three-dimensional(3D) printing and drawing lithography. It further analyzes the characteristics and limitations of existing manufacturing technologies and points out that the combination of various manufacturing technologies can improve production efficiency to a certain extent. In addition, this paper looks forward to the future trends of HMN manufacturing technology and proposes possible directions for its development. In conclusion, it is expected that this review can provide new ideas and references for follow-up research.

关 键 词：微针 空心微针 制造技术 工艺路线 空心微针材料 

分 类 号：R318[医药卫生—生物医学工程]