福建省泉州市2024年1例人感染动物源性H5N6流感病例调查处置情况  

Investigation of H5N6 avian influenza virus in a human infection case in Quanzhou City,Fujian Province,2024

作　　者：刘江艺 潘欢欢 黄歆岚 陈志扬 陈晓玲[1] 李锋平[1] 郑友限 王伟明 LIU Jiangyi;PAN Huanhuan;HUANG Xinlan;CHEN Zhiyang;CHEN Xiaoling;LI Fengping;ZHENG Youxian;WANG Weiming(The Affiliated Quanzhou Center for Disease Control and Prevention of Fujian Medical University,Quanzhou,Fujian 362000,China)

机构地区：[1]福建医科大学附属泉州市疾病预防控制中心,福建泉州362000

出　　处：《中国热带医学》2025年第3期380-384,共5页China Tropical Medicine

基　　金：福建省泉州市科技计划项目(No.2024NY122)。

摘　　要：对福建省泉州市2024年1起人感染动物源性H5N6流感疫情的调查和处置情况进行分析,为今后人感染动物源性流感疫情防控提供参考依据。依据《人感染动物源性流感预防控制技术指南(试行)》,采用现场流行病学调查方法,对病例发病诊疗情况、可疑暴露情况、感染来源和途径开展调查,采集病例、密切接触者、相关环境标本进行核酸检测和基因测序。病例为鼻咽癌患者,罹患H5N6流感后迅速进展为重症肺炎并引发多器官衰竭而死亡。5名密切接触者和37名可疑暴露者的H5N6病毒核酸检测结果均为阴性,无二代病例发生。经现场调查及基因测序分析,感染来源较大可能为病例家周边被H5N6病毒污染的散养家禽外环境。鼻咽癌或其他免疫受限疾病患者应做好个人防护,远离禽畜饲养及交易场所,尽量避免与禽类或其他动物的密切接触。应加强对第三方检测机构管理人员的培训,加强专题风险评估工作及风险评估结果的运用,增点扩面加强人感染动物源性流感病毒在养殖场、活禽市场和候鸟栖息地中的常态监测。To analyze the investigation and disposal of an H5N6 human infection with animal derived influenza epidemic in Quanzhou City in 2024,and provide reference for the control and prevention of animal derived influenza epidemics in future.According to Technical Guidelines for Control and Prevention of Human infected with Zoonotic Influenza Viruses(Trial),we investigated the diagnosis and treatment of the case,suspected exposure,infection sources and routes,by the method of field epidemiological investigation.The case,close contacts,and relevant environmental samples were collected for nucleic acid testing and gene sequencing.A nasopharyngeal carcinoma patient who rapidly progressed to severe pneumonia and died of multiple organ failure after being diagnosed with H5N6.The H5N6 virus nucleic acid test results of 5 close contacts and 37 suspected exposed individuals were all negative,and no second-generation cases occurred.Through on-site investigation and genetic sequencing analysis,it is highly likely that the source of infection is the outdoor environment of free range poultry contaminated with H5N6 virus in the vicinity of the patient's home.Patients with nasopharyngeal carcinoma or other immune restricted diseases should take personal protective measures,stay away from poultry and livestock breeding and trading places,and avoid close contact with poultry or other animals as much as possible.We should strengthen the training of management personnel of third-party testing institutions,enhance the work of thematic risk assessment and the application of risk assessment results,and expand the scope of monitoring human infected with zoonotic influenza viruses in breeding farms,live poultry markets,and migratory bird habitats.

关 键 词：人感染动物源性流感 H5N6 流行病学 监测 

分 类 号：R511[医药卫生—内科学]