转录因子和信号调控在肌腱损伤修复中的研究进展  

Research progress of transcription factors and signaling pathways in tendon injury repair

作　　者：李紫琪 刘丽 申景岭 Li Ziqi;Liu Li;Shen Jingling(Institute of Life Sciences,College of Life and Environmental Science,Wenzhou University,Wenzhou 325035,China)

机构地区：[1]温州大学生命与环境科学学院,生命科学研究院,温州325035

出　　处：《国际遗传学杂志》2025年第1期30-37,共8页International Journal of Genetics

摘　　要：肌腱作为一种致密结缔组织,主要通过传递肌肉收缩所产生的机械力来驱动关节运动,其发育过程受到多种信号通路和转录因子的调控。在承受巨大压力或张力时,肌腱和韧带容易发生断裂、撕裂等急性损伤;而慢性的超负荷或衰老引起的组织变性,也会导致常见的肌腱疾病。损伤后的肌腱愈合缓慢,临床肌腱修复依然面临诸多挑战。在肌腱修复过程中,肌腱干/祖细胞(tendon stem/progenitor cells,TSPC)在信号通路和转录因子的精细调控下,参与了损伤的修复和再生,为肌腱疾病的治疗提供了细胞和分子层面的重要基础。因此,本文综述了肌腱损伤修复的分子机制及TSPC相关研究进展,阐明了肌腱干细胞在临床肌腱损伤修复中的应用潜力。Tendons,as dense connective tissues,primarily transmit the mechanical force generated by muscle contraction to drive joint movement.Their development is regulated by various signaling pathways and transcription factors.Tendons and ligaments are prone to acute injuries,such as ruptures and tears,when subjected to excessive pressure or tension.Chronic overload or age-related tissue degeneration can also lead to common tendon disorders.Tendon healing after injury is slow,and clinical tendon repair continues to face significant challenges.During tendon repair,tendon stem/progenitor cells(TSPC),under the precise regulation of signaling pathways and transcription factors,play crucial roles in tissue repair and regeneration,providing a cellular and molecular foundation for the treatment of tendon diseases.This review summarizes the molecular mechanisms of tendon injury repair and the latest research on tendon stem/progenitor cells,highlighting the potential applications of tendon stem cells in the clinical repair of tendon injuries.

关 键 词：肌腱 发育 损伤修复 肌腱干/祖细胞 

分 类 号：R687.2[医药卫生—骨科学]