克罗恩病脑功能改变的功能磁共振成像研究进展  

Progress on functional magnetic resonance imaging study of brain functional changes in Crohn's disease

作　　者：董宇寒 吕宗峻 方婷婷 刘海燕[2] 朱建国[1] Dong Yuhan;Lyu Zongjun;Fang Tingting;Liu Haiyan;Zhu Jianguo(Department of Radiology,the Second Affiliated Hospital,Nanjing Medical University,Nanjing 210011,China;Department of Science and Education,Jurong People's Hospital,Zhenjiang 212400,China)

机构地区：[1]南京医科大学第二附属医院医学影像科,南京210011 [2]句容市人民医院科教科,镇江212400

出　　处：《中华炎性肠病杂志(中英文)》2025年第2期154-157,共4页Chinese Journal of Inflammatory Bowel Diseases

基　　金：江苏省卫健委高层次卫生人才“六个一工程”科研项目(LGY2018072);南京医科大学科技发展重点项目(2015NJMUZD035)。

摘　　要：克罗恩病(CD)是一种难以治愈且易反复的肠道慢性炎症性疾病,确切病因尚未明确。除肠道症状外,该病还常伴发多种肠外表现。CD患者的中枢神经系统活动异常与脑-肠轴密切相关,这可能是患者焦虑抑郁等不良情绪高发的原因之一。功能磁共振成像技术(fMRI)因其非侵入性、高空间分辨率和全脑覆盖等优势在神经胃肠病学领域得到广泛应用。本文综述了fMRI在CD脑功能研究中的应用与进展,旨在分析并总结疾病对脑功能的影响,为临床诊疗和科研提供参考。Crohn's disease(CD)is a refractory and recurrent chronic inflammatory bowel disease with an unclear etiology.In addition to intestinal symptoms,the disease is often accompanied by various extraintestinal manifestations.Studies have found that abnormalities in central nervous system activity in CD patients are closely related to the brain-gut axis,which may be one of the reasons for the high incidence of adverse emotions such as anxiety and depression.Functional magnetic resonance imaging(fMRI)has been widely used in the field of neurogastroenterology due to its non-invasiveness,high spatial resolution,and whole-brain coverage.This article reviews the application and progress of fMRI in CD brain functional study,aiming to comprehensively analyze and integrate the impact of the disease on brain function and provide a reference for clinical diagnosis,treatment,and future research.

关 键 词：克罗恩病 功能磁共振成像 脑功能 脑-肠轴 焦虑 抑郁 

分 类 号：R445.2[医药卫生—影像医学与核医学]