表观遗传调控在肺动脉高压发生发展中的作用机制  

Role of epigenetic modulation in pulmonary arterial hypertension

作　　者：孙雪明 刘瀚旻[1,2,3,4,5] SUN Xueming;LIU Hanmin(Department of Pediatric Pulmonology and Immunology,West China Second University Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China;Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,Chengdu,Sichuan 610041,P.R.China;NHC Key Laboratory of Chronobiology(Sichuan University),Chengdu,Sichuan 610041,P.R.China;The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital and School of Life Sciences of Fudan University,West China Institute of Women and Children’s Health,Sichuan University,Chengdu,Sichuan 610041,P.R.China;Sichuan Birth Defects Clinical Research Center,West China Second University Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China)

机构地区：[1]四川大学华西第二医院小儿呼吸与免疫科,成都610041 [2]四川大学妇女儿童出生缺陷及相关疾病教育部重点实验室,成都610041 [3]四川大学国家卫生健康委员会慢性生物学重点实验室,成都610041 [4]四川大学华西第二医院/复旦大学生命科学学院肺发育与相关疾病联合实验室、四川大学华西第二医院妇幼保健研究所,成都610041 [5]四川大学华西第二医院四川省出生缺陷临床研究中心,成都610041

出　　处：《华西医学》2025年第4期626-633,共8页West China Medical Journal

摘　　要：肺动脉高压是一种致命的复杂疾病,其特点是多因素参与肺血管重塑,导致心力衰竭。这种疾病难以治疗,长期预后不良。最近的研究强调了表观遗传调控在肺动脉高压病理生理学进展中的重要作用,为改善临床预后提供了新的治疗方法。该文总结了表观遗传调控在肺动脉高压发病和进展中的作用,重点关注了脱氧核糖核酸甲基化、核糖核酸甲基化、组蛋白修饰和非编码核糖核酸,以了解表观遗传调控在肺动脉高压疾病中的作用并确定新的评估指标和治疗靶点,进而改善肺动脉高压预后。Pulmonary arterial hypertension(PAH)is a fatal and complex disease characterized by multifactorial involvement in pulmonary vascular remodeling,leading to heart failure.It is difficult to treat and has a poor long-term prognosis.Recent studies highlight the significant role of epigenetic modulation in the pathophysiological progression of PAH,offering new therapeutic approaches to improve clinical outcomes.This article summarizes the role of epigenetic modulation in the development and progression of PAH,focusing on deoxyribonucleic acid methylation,ribonucleic acid methylation,histone modifications,and non-coding ribonucleic acid,in order to understand the role of epigenetic modulation in PAH and identifying new evaluation indexes and therapeutic targets,thereby improving the prognosis of PAH.

关 键 词：肺动脉高压 表观遗传调控 甲基化 非编码核糖核酸 

分 类 号：R544.1[医药卫生—心血管疾病]