山东省299219名儿童接种第5剂次无细胞百白破联合疫苗后的疑似预防接种异常反应分析  

Analysis on adverse events following immunization of 299219 children who received the fifth dose of diphtheria,tetanus and acellular pertussis combined vaccine in Shandong Province

作　　者：谢萌 冯霞 孙辉峰 熊萍[1] 张伟燕[1] 许青[1] 赵敏[1] 张丽[1] Xie Meng;Feng Xia;Sun Huifeng;Xiong Ping;Zhang Weiyan;Xu Qing;Zhao Min;Zhang Li(Institute for Immunization Management,Shandong Center for Disease Control and Prevention,Ji′nan 250014,China)

机构地区：[1]山东省疾病预防控制中心免疫预防管理所,济南250014

出　　处：《中华预防医学杂志》2025年第4期474-477,共4页Chinese Journal of Preventive Medicine

基　　金：山东省医药卫生科技项目(202412051236);山东省医药卫生科技发展计划(202012051251);山东省政府泰山学者工程(tstp20221164)。

摘　　要：2018年7月23日至2019年12月31日,山东省共有299219名儿童接种第5剂次无细胞百白破联合疫苗(DTaP),其中<2、2、3、4、5、≥6岁儿童分别为20名(0.01%)、273996名(91.57%)、20242名(6.76%)、3932名(1.31%)、963名(0.32%)和66名(0.02%)。接种第5剂次DTaP后共报告疑似预防接种异常反应(AEFI)1972例,发生率为659.05/10万剂。其中,一般反应1718例(574.16/10万剂),异常反应247例(82.55/10万剂)。接种DTaP后AEFI、一般反应、异常反应报告发生率随接种剂次增加呈上升趋势(均P<0.001);异常反应中,严重异常反应10例(3.34/10万剂)。From July 23,2018,to December 31,2019,a total of 299219 children in Shandong Province received the fifth dose of the diphtheria,tetanus,and acellular pertussis combined vaccine(DTaP).Among these recipients,the distribution by age was as follows:20 children under 2 years old(0.01%),273996 children aged 2 years(91.57%),20242 children aged 3 years(6.76%),3932 children aged 4 years(1.31%),963 children aged 5 years(0.32%),and 66 children aged 6 years and above(0.02%).In total,1972 cases of adverse events following immunization(AEFI)were reported after the administration of the fifth dose of DTaP,resulting in an incidence rate of 659.05 per 100000 doses.Among these,1718 cases were classified as common vaccine reactions,with an incidence rate of 574.16 per 100000 doses,while 247 cases were identified as rare reactions,yielding an incidence rate of 82.55 per 100000 doses.The incidence of AEFIs,as well as the rates of common and rare reactions,exhibited a significant increasing trend with the number of doses administered(all P<0.001).Among the rare reactions,there were 10 cases classified as severe,resulting in a reported incidence of 3.34 per 100000 doses.

关 键 词：无细胞百白破联合疫苗 疑似预防接种异常反应 第5剂次 

分 类 号：R186[医药卫生—流行病学]