饮食与营养因素影响系统性红斑狼疮的研究进展  

Research progress of the influence of dietary and nutritional factors on systemic lupus erythematosus

作　　者：邓雅方 王迁 Deng Yafang;Wang Qian(Department of Rheumatology and Clinical Immunology,Peking Union Medical College Hospital(PUMCH),Chinese Academy of Medical Sciences and Peking Union Medical College/National Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID),Ministry of Science and Technology/State Key Laboratory of Complex Severe and Rare Diseases/Key Laboratory of Rheumatology and Clinical Immunology,Ministry of Education,Beijing 100730,China;School of Medicine,Tsinghua Medicine,Tsinghua University,Beijing 100084,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院风湿免疫科,国家皮肤与免疫疾病临床医学研究中心,疑难重症及罕见病国家重点实验室,风湿免疫病学教育部重点实验室,北京100730 [2]清华大学医学院,北京100084

出　　处：《中华预防医学杂志》2025年第4期526-534,共9页Chinese Journal of Preventive Medicine

基　　金：中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-005);北京协和医院中央高水平医院临床科研专项(2022-PUMCH-B-013,D-009)。

摘　　要：系统性红斑狼疮(SLE)是一种多器官受累的自身免疫性疾病,其主要特征为机体免疫系统异常激活,进而攻击自身组织和器官,其确切发病机制尚未完全阐明。近年来,众多研究揭示饮食与营养因素在SLE的发病、进展及治疗过程中扮演着关键的调节角色,SLE患者有望借助饮食和营养的合理调整来改善疾病状态、提高生活质量。本文综合梳理了多种营养元素和饮食方案对SLE发病、进展与治疗影响的基础与临床研究进展,并深入分析了其中作用机制的多元层次,以期为后续相关研究提供有益参考。Systemic lupus erythematosus(SLE)is a multisystem autoimmune disease characterized by abnormal activation of the immune system,leading to damage of the body′s own tissues and organs.The exact mechanisms underlying the pathogenesis of SLE remain incompletely understood.Increasing evidence underscores the significant role of dietary and nutritional factors in the onset,progression,and management of SLE.Modifications in dietary patterns and nutritional interventions offer a promising strategy for improving clinical outcomes and enhancing the quality of life in patients with SLE.This article synthesizes recent basic and clinical research on the impact of various nutritional elements and dietary approaches on the development,progression,and treatment of SLE.It also explores the mechanisms at different levels,aiming to provide valuable insights for future research in this area.

关 键 词：自身免疫性疾病 系统性红斑狼疮 营养因素 饮食干预 

分 类 号：R593.24[医药卫生—内科学]