液态芯片技术及其在临床实验诊断中的应用进展  

Liquid chip technology and its application in clinical laboratory diagnosis

作　　者：高浩栋 汤馨怡 胡新阳[2] 赵文卓 孙巍[2] 余晓敏[3] 赵秘胜 Gao Haodong;Tang Xinyi;Hu Xinyang;Zhao Wenzhuo;Sun Wei;Yu Xiaomin;Zhao Misheng(School of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Wenzhou 325000,China;Department of Transfusion,Peking University Cancer Hospital&Institute,Beijing 100142,China;Department of Clinical Laboratory,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China)

机构地区：[1]温州医科大学检验医学院(生命科学学院),温州325000 [2]北京大学肿瘤医院输血科,北京100142 [3]温州医科大学附属第一医院医学检验中心,温州325000

出　　处：《中华预防医学杂志》2025年第4期542-548,共7页Chinese Journal of Preventive Medicine

摘　　要：液态芯片技术以液体为载体,具有高通量、重复性好、敏感性高、样本用量少、分析速度快等优势,可实现液相反应体系蛋白质、核酸等生物大分子的多重检测,目前已广泛应用于肿瘤、自身免疫性疾病、过敏性疾病、细胞因子相关疾病,以及感染性疾病的实验室诊断。本文就液态芯片技术的原理、检测性能、临床应用、未来展望进行了阐述。Liquid chip technology is based on liquid carrier.Comparing to the traditional detection methods,it has unique characteristics such as multiple detection ability,high throughput,high sensitivity,good repeatability,less sample and fast analysis.It can analyse proteins,nucleic acids and other biological molecules in liquid.At present,it has been widely used in the laboratory diagnosis of tumors,autoimmune diseases,allergic diseases,cytokines related diseases,as well as infectious diseases.This article discussed the principles,detection performances,clinical applications and future prospects of liquid chip technology.

关 键 词：液态芯片技术 微球 多重检测 临床应用 

分 类 号：R446[医药卫生—诊断学]