红毛藻多糖片剂制备综合实验设计  

Comprehensive experimental design of preparation of Bangia fusco-purpurea polysaccharide tablets

作　　者：吴靖娜 周碧盈 丘英珊 石惠芳 苏筱 苏海燕 WU Jingna;ZHOU Biying;QIU Yingshan;SHI Huifang;SU Xiao;SU Haiyan(School of Pharmacy,Xiamen Medical College,Xiamen,Fujian 361023,China)

机构地区：[1]厦门医学院药学院,福建厦门361023

出　　处：《职业与健康》2025年第5期617-621,共5页Occupation and Health

基　　金：厦门市教育科学“十四五”规划课题(22086)。

摘　　要：目的以红毛藻为原料制备片剂,建立红毛藻多糖片剂的评价方法。方法根据前期的科研成果以及生产实际需求,设计了“红毛藻多糖片剂制备综合实验”,以红毛藻多糖为主要原料,片剂外观、重量差异、硬度、脆碎度和崩解时限为评价指标,采用单因素和正交试验优化片剂制备工艺,并对红毛藻多糖片剂进行糖包衣改善其性能。结果获得红毛藻多糖片剂的最优配方:微晶纤维素(microcrystalline cellulose,MCC)37.25%,玉米淀粉37.25%,交联羧甲基纤维素钠(cross-linked sodium carboxymethyl cellulose,CC-Na)7%,硬脂酸镁0.3%,菊粉8.2%,红毛藻多糖10%;低场核磁检测表明糖包衣有利于增强片剂在储藏过程中的稳定性。结论所建立的红毛藻多糖片剂评价方法实验条件简单、结果可靠,适合红毛藻多糖片剂的评价。Objective To prepare Bangia fusco-purpurea polysaccharide from Bangia fusco-purpurea,and establish an evaluation method for Bangia fusco-purpurea polysaccharide tablets.Methods According to previous scientific research achievements and actual production needs,a"comprehensive experiment on the preparation of Bangia fusco-purpurea polysaccharide tablets"was designed.The polysaccharide isolated from Bangia fusco-purpurea was used as the main raw material,the appearance,weight difference,hardness,fragility,and disintegration time of the tablets were used as evaluation indicators.The single-factor and orthogonal experiments were used to optimize the tablet preparation process,and a sugar coating was applied to the Bangia fuscopurpurea polysaccharide tablets to improve their properties.Results The optimal formula for Bangia fusco-purpurea polysaccharide tablets was found to be:microcrystalline cellulose(MCC)37.25%,corn starch 37.25%,cross-linked sodium carboxymethyl cellulose(CC-Na)7%,magnesium stearate 0.3%,inulin 8.2%,and Bangia fusco-purpurea polysaccharide 10%.The low-field nuclear magnetic resonance detection showed that sugar coating enhances the stability of the tablets during storage.Conclusion The established evaluation method for Bangia fusco-purpurea polysaccharide tablets has simple experimental conditions and reliable results,which is suitable for the evaluation of Bangia fusco-purpurea polysaccharide tablets.

关 键 词：多糖 片剂 糖包衣 正交优化 

分 类 号：R944.4[医药卫生—药剂学]