膝骨关节炎用药特点的古代数据挖掘  

Ancient data mining on drug characteristics of knee osteoarthritis

作　　者：孟梓涵 虞跃跃 史晓燚 马欣宇 武叮叮 张旭 李贺祎 王静雅 张莉苑 赵合立 MENG Zihan;YU Yueyue;SHI Xiaoyi;MA Xinyu;WU Dingding;ZHANG Xu;LI Heyi;WANG Jingya;ZHANG Liyuan;ZHAO Heli(College of Traditional Chinese Medicine,North China University of Science and Technology,Tangshan 063210,Hebei,China;Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Diabetes and Its Complications,Tangshan 063210,Hebei,China)

机构地区：[1]华北理工大学中医学院,河北唐山063210 [2]河北省中西医结合防治糖尿病及其并发症重点实验室,河北唐山0632101

出　　处：《中国现代医生》2025年第12期1-4,48,共5页China Modern Doctor

基　　金：国家级大学生创新训练项目(202310081043)。

摘　　要：目的分析古代文献中治疗膝骨关节炎(knee osteoarthritis,KOA)的方剂,探索其应用规律,为临床治疗提供参考。方法收集古代文献中治疗膝骨关节炎的方剂,使用Excel 2016建立数据库并进行频数分析,应用SPSS Modeler 18.0软件、Lantern 5.0进行关联规则和隐结构模型分析,探讨治疗规律。结果共收集373首方剂,涉及421种中药,总计用药频次为3894次,使用频次最高的药物为当归,药物功效以补虚、解表、祛风湿为主,药性偏温,药味偏辛、甘、苦,多归脾、肾经。关联规则分析得到13条强关联规则,如川芎+牛膝–当归,萆薢–牛膝等。隐结构分析得到10个隐变量,推断出4个综合聚类和4个核心方剂,常见证候包括风湿型、风寒湿型、风湿热型和气血亏虚型。结论古代文献治疗KOA以祛风除湿为核心,兼顾正虚与邪实,灵活运用补脾肾、清湿热、补气血等药物。Objective To analyze ancient prescriptions for knee osteoarthritis(KOA),and explore their application patterns,for providing clinical reference value.Methods Prescriptions were collected from ancient documents,and a database was created by using Excel 2016 for frequency analysis.Association rules and hidden structures were analyzed by using SPSS Modeler 18.0 and Lantern 5.0.Results A total of 373 prescriptions and 421 herbs were collected,with 3894 times of frequency of medication.Danggui was the most frequently used herb.Herbs primarily tonified deficiencies,relieved exterior symptoms,and expelled wind-dampness,with warm properties and pungent,sweet,or bitter tastes,mainly targeting the spleen and kidney meridians.Thirteen strong association rules were identified,including Chuanxiong+Niuxi-Danggui,and Bixie-Niuxi.Hidden structure analysis revealed 10 variables,leading to 4 clusters and 4 core prescriptions.Common syndromes included wind-damp,wind-cold-damp,wind-damp-heat,and qi-blood deficiency.Conclusion The treatment of KOA in ancient literature focuses on dispelling wind and removing dampness,taking into account both positive deficiency and evil excess,flexible use of tonifying spleen and kidney,clearing dampness-heat,tonifying Qi and blood and other drugs.

关 键 词：膝骨关节炎 隐结构 关联规则分析 用药规律 

分 类 号：R274.9[医药卫生—中西医结合]