基于数据挖掘探讨运用“少阳为枢”理论治疗小儿夜咳的用药规律  

Exploring the medication patterns of using the“Shaoyang as the pivot”theory to treat children’s night cough based on data mining

作　　者：杨亚峰 王晓燕 刘丽平 孔令霞 郑晓娟 陈茁 YANG Yafeng;WANG Xiaoyan;LIU Liping;KONG Lingxia;ZHENG Xiaojuan;CHEN Zhuo(Department of Pediatrics,Zhengzhou TCM Hospital,Zhengzhou 450007,Henan,China;School of Pediatrics,Henan University of Traditional Chinese Medicine,Zhengzhou 450046,Henan,China)

机构地区：[1]郑州市中医院儿科,河南郑州450007 [2]河南中医药大学儿科医学院,河南郑州450046

出　　处：《中国现代医生》2025年第12期72-75,112,共5页China Modern Doctor

基　　金：河南省中医药科学研究专项课题(2023ZY3022)。

摘　　要：目的探讨基于“少阳为枢”理论治疗小儿夜咳的用药规律。方法纳入189例夜咳患儿病案,含224首处方。应用中医传承辅助平台分析夜咳的时辰分布、证候类型及药物的四气、五味、归经等;运用频次统计、关联规则分析及聚类分析提炼小儿夜咳的用药规律。结果咳嗽时辰以寅时发作者最多。证候类型以少阳兼证为主。高频核心药物为柴胡、黄芩、半夏等17味,组方特征为小柴胡汤去人参、生姜、大枣,加五味子、当归、杏仁。随证配伍用药:合并痰饮证加麻杏二三汤,食滞证加曲麦二陈汤,气虚证合四君子汤,阴虚证伍麦味地黄汤,痰热证配苇茎汤。结论以调和少阳枢机为基本治则,根据兼夹病机灵活化裁经方,形成基于“少阳为枢”理论的夜咳辨治体系,具有鲜明的临床特色。Objective To exploring the drug rules for treating children’s night cough based on the theory of“Shaoyang as the pivot”.Methods 189 cases of children with night cough were included,and 224 prescriptions.Used the Traditional Chinese Medicine Inheritance Assistance Platform to analyze the time distribution,syndrome types,and four nature,five flavors,and channel tropism of diseases.Used frequency statistics,association rule analysis,and cluster analysis to extract drug patterns for pediatric night cough.Results Coughing occured most frequently during the Yin period.The syndrome type was mainly Shaoyang syndrome.The high-frequency core drugs were Chaihu,Huangqin,and Banxia,etc..The prescription characteristics were Xiaochaihu decoction without Renshen,Shengjiang,and Dazao,and added Wuweizi,Danggui and Xingren.The drugs were used flexibly according to the syndromes:Maxing Er San decoction was added to the phlegm and drink syndrome,Qumai Er Chen decoction was added to the food stagnation syndrome,Sijunzi decoction was added to the qi deficiency syndrome,Maiwei Dihuang decoction was added to the yin deficiency syndrome,and Weijing decoction was added to the phlegm and heat syndrome.Conclusion Based on the basic principle of harmonizing Shaoyang,and according to the disease mechanism,the classical prescription is flexibly used,forming a night cough treatment system based on the“Shaoyang as the pivot”theory,with distinct clinical characteristics.

关 键 词：夜咳 数据挖掘 少阳理论 名医经验 

分 类 号：R272.6[医药卫生—中医儿科学]