坏死性凋亡在病毒性感染中作用机制的研究进展  

Research advances on necroptosis in viral infections

作　　者：刘宜雨 牛静轶 代宇 叶超[1] LIU Yiyu;NIU Jingyi;DAI Yu;YE Chao(College of Veterinary Medicine,Southwest University,Chongqing 400715,China)

机构地区：[1]西南大学动物医学院,重庆400715

出　　处：《中国兽医学报》2025年第1期153-162,共10页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金资助项目(32372982);中央高校基本科研业务费资助项目(SWU-KT22016);国家生猪技术创新中心资助项目(NCTIP-XD/C17);重庆生猪产业技术体系资助项目(20211105)。

摘　　要：程序性细胞死亡在机体的生长发育及组织器官的稳态中发挥着重要作用。坏死性凋亡作为一种新型的程序性细胞死亡模式,具有坏死的形态学特征,能够导致细胞崩裂并释放大量损伤相关分子模式,在多种疾病的发生和发展中起着重要作用。病毒性感染疾病严重危害人类和家畜的健康,已有研究证实在病毒性感染中存在坏死性凋亡的细胞死亡途径。本文通过综述坏死性凋亡在病毒性感染中的研究现状,阐明病毒感染与坏死性凋亡之间的相互调控分子机制,以及坏死性凋亡抑制剂的应用进展,旨在为病毒性感染的防治提供新的思路。Programmed cell death plays an important role in the growth and development of organism and homeostasis of tissues and organs.Necroptosis,a new mode of programmed cell death,characterized by necrosis in morphology,can cause cell breakdown and release of a significant number of damage-associated molecular patterns,which play an important role in the occurrence and development of diseases.Viral infection is a serious health risk to both humans and domestic animals.Research has confirmed that necroptosis functions as a cell death pathway in viral infections.In this paper,we review the current research advances on necroptosis related to viral infections,elucidate the molecular mechanism of mutual regulation between viral infection and necroptosis,and discuss the progress in the application of necroptosis inhibitors,to provide new ideas for the prevention and treatment of viral infections.

关 键 词：坏死性凋亡 病毒 病毒性感染 分子机制 抑制剂 

分 类 号：S855.3[农业科学—临床兽医学]