氧化应激在糖尿病并发症发病机制及治疗中的研究进展  

Research progress of oxidative stress in the pathogenesis and treatment of diabetic complications

作　　者：韩宇南 李琳[1] 李玉洪[1] 陈娜娜 王勇翔 HAN Yunan;LI Lin;LI Yuhong;CHEN Nana;WANG Yongxiang(The First Affliated Hospital of Yangtze University,Jingzhou,Hubei 434000,China)

机构地区：[1]长江大学附属第一医院,湖北荆州434000

出　　处：《中国临床研究》2025年第4期515-519,共5页Chinese Journal of Clinical Research

基　　金：湖北省荆州市2023年医疗卫生科技计划项目(2023HC20)。

摘　　要：糖尿病患者长期受高血糖影响会发生多种并发症,严重影响患者的生命安全及生活质量。糖尿病患者的高糖状态可诱导氧化应激,氧化应激促使产生大量活性氧自由基,破坏氧化与抗氧化平衡,诱导炎性反应,导致器官损害,引发糖尿病肾病、糖尿病足、糖尿病视网膜病变、糖尿病心血管疾病、糖尿病神经病变等一系列并发症。本研究对氧化应激在以上5种并发症中的发病机制及在治疗中的作用进行综述,为临床防治糖尿病并发症提供参考。Chronic hyperglycemia in diabetic patients can lead to various complications,severely impacting patients'life expectancy and quality of life.The hyperglycemic state in diabetes induces oxidative stress,which in turn generates excessive reactive oxygen species(ROS).These ROS disrupt the balance between oxidation and antioxidation,trigger inflammatory responses,and cause organ damage.This cascade of events leads to diabetic complications such as diabetic nephropathy,diabetic foot,diabetic retinopathy,diabetic cardiovascular disease,and diabetic neuropathy.This review summarizes the role of oxidative stress in the pathogenesis and treatment of these five diabetic complications,providing insights for clinical prevention and management of diabetic complications.

关 键 词：糖尿病 糖尿病足 糖尿病肾病 氧化应激 并发症 发病机制 

分 类 号：R587.2[医药卫生—内分泌]