2型糖尿病缓解治疗的研究进展  

Treatment progress in remission of type 2 diabetes

作　　者：张咪咪 唐伟 ZHANG Mimi;TANG Wei(Department of Endocrinology,Geriatric Hospital of Nanjing Medical University,Nanjing,Jiangsu 210024,China)

机构地区：[1]南京医科大学附属老年医院内分泌科,江苏南京210024

出　　处：《中国临床研究》2025年第4期520-523,共4页Chinese Journal of Clinical Research

基　　金：江苏省重点研发计划社会发展项目(BE2023774);江苏省老年健康科研项目(LR2022005)。

摘　　要：2型糖尿病是一种可缓解的疾病,患者如停用降糖药物≥3个月后糖化血红蛋白(HbA1c)<6.5%,空腹血糖<7.0 mmol/L,则被定义为糖尿病缓解。胰岛自身抗体、糖尿病病程、身体质量指数及腰围、胰岛功能、基线HbA1c是糖尿病缓解的独立影响因素。生活方式干预、限制能量摄入和减重是诱导和维持缓解的主要策略,药物治疗、代谢手术是实现缓解的重要措施。缓解机制主要是减少脂质沉积,解除糖脂毒性,进而改善胰岛素抵抗和β细胞功能。Type 2 diabetes is a reversible disease.The remission of type 2 diabetes is defined as maintaining a glycosylated hemoglobin(HbAlc)level<6.5%and fasting plasma glucose<7.0 mmol/L for at least 3 months after discontinuation of glucose-lowering medications.Factors independently associated with diabetes remission include islet autoantibodies,duration of diabetes,body mass index,waist circumference,pancreatic islet function,and baseline HbAlc.Lifestyle interventions,caloric restriction,and weight loss are the primary strategies for inducing and maintaining remission,while pharmacological treatment and metabolic surgery play important roles in achieving remssion.The mechanisms of remission primarily involve reducing lipid accumulation,alleviating glucolipotoxicity,and improving insulin resistance andβ-cell function.

关 键 词：糖尿病 糖尿病缓解 生活方式干预 胰岛素 代谢手术 奥利司他 降糖药物 菌群治疗 细胞治疗 

分 类 号：R587.1[医药卫生—内分泌]