血清可溶性生长刺激表达基因2蛋白在不同类型心脏病心力衰竭患者中的诊断  

Diagnostic value of serum soluble suppression of tumorigenicity 2 in patients with heart failure in different types of heart diseases

作　　者：夏莉 尹伊 周德伟 吴家明 王宏志 XIA Li;YIN Yi;ZHOU Dewei;WU Jiaming;WANG Hongzhi(Department of Internal Medicine,Hefei Cancer Hospital,Chinese Academy of Sciences,Hefei,Anhui 230000,China;不详)

机构地区：[1]中国科学院合肥肿瘤医院内科,安徽合肥230000 [2]中国科学院合肥肿瘤医院医院临床转化中心,安徽合肥230000 [3]中国科学院合肥肿瘤医院生物医学大数据中心,安徽合肥230000

出　　处：《中国临床研究》2025年第4期574-577,共4页Chinese Journal of Clinical Research

基　　金：安徽省临床医学研究转化专项(202304295107020092)。

摘　　要：目的 分析不同类型心脏病患者发生心力衰竭时的血清可溶性生长刺激表达基因2蛋白(sST2)水平的变化,并分析sST2对不同严重程度心力衰竭的诊断价值。方法 选取2021年1月至2022年5月中国科学院合肥肿瘤医院康复内科收治的74例心力衰竭患者,按心脏病类型分为冠心病组(24例),心房颤动组(25例),以及高血压性心脏病组(25例),另选取同期26例健康体检者作为对照组。检测观察组与对照组血清sST2水平;分析血清sST2水平在不同严重程度心力衰竭患者中的差异性,比较sST2、N末端B型利钠肽原(NT-proBNP)的诊断能力。结果 冠心病组、心房颤动组及高血压心脏病组患者血清sST2分别为(50.02±19.43)ng/mL、(57.26±19.07)ng/mL和(44.79±16.50)ng/mL,均显著高于对照组[(20.55±4.33)ng/mL,P<0.01]。随着心功能分级增加,血清sST2水平也随之升高,差异有统计学意义(F=15.097,P<0.01)。血清sST2联合NT-proBNP诊断不同严重程度心力衰竭的特异度为83.33%,灵敏度为92.00%,曲线下面积(AUC)最高,为0.95。结论 血清sST2是不同类型心脏病导致的心力衰竭的重要指标,联合NT-proBNP诊断此病效能较好。Objective To observe the changes of soluble growth stimulation expression gene 2(sST2)level in patients with heart failure in dfferent types of heart diseases,and analyze the diagnostic value of sST2 in heart failure.Methods A total of 74 patients with heart failure admitted to the Department of Rehabilitation,Hefei Cancer Hospital,Chinese Academy of Sciences,from January 2021 to May 2022 were selected,including 24 patients with coronary artery disease(CAD group),25 patients with atrial fibrillation(AF group)and 25 patients with hypertensive heart disease(HHD group).Additional 26 healthy individuals during the same period were selected as the control group.Serum sST2 levels were measured and compared between the observation groups and the control group.The differences in serum sST2 levels in patients with different severities of heart failure were analyzed,and the diagnostic efficacy of sST2 and N-terminal pro B-type natriuretic peptide(NT-proBNP)was compared.Results The serum sST2 levels in the CAD group,AF group,and HHD group were(50.02±19.43)ng/mL,(57.26±19.07)ng/mL,and(44.79±16.50)ng/mL,D0I:10.13429/j.cnki.cjcr.2025.04.017 respectively,which were significantly higher than that in the control group[(20.55±4.33)ng/mL,P<0.01].As the heart failure grade increased,the serum sST2 levels also increased,with statistical significance(F=15.097,P<0.01).The specificity of serum sST2 combined with NT-proBNP in diagnosing heart failure of different severities was 83.33%,the sensitivity was 92.00%,and the area under the curve(AUC)was 0.95.Conclusion The level of serum sST2 is an important indicator of heart failure caused by different types of heart disease,and combined with NT-proBNP is effective in the diagnosis of this disease.

关 键 词：心脏疾病 可溶性生长刺激表达基因2蛋白 N末端B型利钠肽原 心力衰竭 心房颤动 高血压性心脏病 冠状动脉粥样硬化性心脏病 

分 类 号：R541[医药卫生—心血管疾病]