血清CTRP7水平与2型糖尿病相关性的研究进展  

Research progress on the correlation between serum CTRP7 level and type 2 diabetes mellitus

作　　者：白家琪 张林[2] BAI Jiaqi;ZHANG Lin(Graduate School of Inner Mongolia Medical University,Hohhot,Inner Mongolia O10000,China;不详)

机构地区：[1]内蒙古医科大学研究生院,内蒙古呼和浩特010000 [2]巴彦淖尔市医院内分泌科,内蒙古巴彦淖尔015000

出　　处：《中国临床研究》2025年第4期629-632,637,共5页Chinese Journal of Clinical Research

基　　金：内蒙古自治区科技计划项目(2023YFSH0045)。

摘　　要：补体C1q肿瘤坏死因子相关蛋白7(CTRP7)是新近发现的脂肪因子。研究表明,肥胖人群中的循环CTRP7水平显著高于体重正常人群,高胰岛素引起的胰岛素抵抗促进人体CTRP7的分泌,CTRP7参与人体糖、脂代谢,促进炎症的发生和细胞氧化应激,影响胰岛素抵抗过程,从而参与2型糖尿病的发生发展。本文对血清CTRP7的生物学特性、代谢功能及其与2型糖尿病发生发展的相关性进行综述。Complement Clq tumor necrosis factor-related protein 7(CTRP7)is a newly discovered adipokine.It has been shown that circulating CTRP7 level in the obese population is significantly higher than that in the population with normal weight,and insulin resistance caused by hyperinsulinism promotes the secretion of CTRP7 in the body.CTRP7 is involved in glucose and lipid metabolism,promotes inflammation and cellular oxidative stress,and influences the process of insulin resistance,thus participating in the development of type 2 diabetes mellitus.This article reviews the biological characteristics,metabolic functions of serum CTRP7,and its correlation with the development and progression of type 2 diabetes mellitus.

关 键 词：补体C1q肿瘤坏死因子相关蛋白7 2型糖尿病 胰岛素抵抗 肥胖 

分 类 号：R587.1[医药卫生—内分泌]