羟基磷灰石纳米粒子表面修饰在抗菌性能方面的研究进展  

Progress in surface modification of hydroxyapatite nanoparticles in antibacterial properties

作　　者：汪明康 徐旭[2] WANG Mingkang;XU Xu(School of Stomatology,Zhejiang Chinese Medicine University,Hangzhou,Zhejiang 310053,China;不详)

机构地区：[1]浙江中医药大学口腔医学院,浙江杭州310053 [2]衢州市人民医院口腔科,浙江衢州324002

出　　处：《中国临床研究》2025年第4期647-651,共5页Chinese Journal of Clinical Research

基　　金：浙江省医药卫生科技计划项目(2018KY878);衢州市科技计划项目(2023K140)。

摘　　要：羟基磷灰石作为人体骨骼和牙齿中的主要无机成分,具备良好的生物相容性和生物活性。近年来,纳米羟基磷灰石凭借其卓越的骨传导性、生物降解性、生物相容性等诸多特性,成为研究热点,但缺乏抗菌活性是其一个明显缺陷。通过对纳米羟基磷灰石进行表面修饰,能够改善它的理化性能、生物学性能,还能赋予其优异的抗菌性能。本文介绍了离子掺杂、表面接枝两种表面修饰的途径,同时针对表面修饰羟基磷灰石纳米粒子在抗菌性能方面的研究进展进行了论述,总结并展望了现阶段这些方法的缺陷及未来发展方向。Hydroxyapatite,the primary inorganic constituent of human bone and teeth,is renowned for its exceptional biocompatibility and biological activity.Recently,nano-hydroxyapatite has garnered significant attention due to its superior bone conductivity,biodegradability,and biocompatibility.However,its lack of inherent antibacterial properties poses a notable limitation.Surface modification of nano-hydroxyapatite ffers a promising strategy to enhance its physicochemical and biological characteristics,while imparting it with robust antibacterial capabilities.This paper delves into two prominent surface modification methods:ion doping and surface grafting.Additionally,this article explores the antibacterial efficacy of surface-modified hydroxyapatite nanoparticles and provides a comprehensive overview of the limitations and future prospects of these techniques.

关 键 词：羟基磷灰石 纳米材料 表面修饰 抗菌性能 

分 类 号：R318.08[医药卫生—生物医学工程]