儿童胼胝体径线在MRI正中矢状面的性别差异  

Gender Difference of Corpus Callosum Diameter in Midsagittal Plane of MRI in Children

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作  者:陆宽 邓杰 郑勇 晁芳 邱丽华[1,4] LU Kuan;DENG Jie;ZHENG Yong(Medical Imaging Center,the Second People’s Hospital of Yibin,Yibin,Sichuan Province 644000,P.R China)

机构地区:[1]宜宾市第二人民医院医学影像中心,644000 [2]宜宾市第四人民医院放射科 [3]四川省妇幼保健院放射科,成都615000 [4]宜宾市第二人民医院·四川大学华西医院宜宾医院临床医学研究与转化中心,神经影像大数据研究中心,644000

出  处:《临床放射学杂志》2025年第5期926-931,共6页Journal of Clinical Radiology

摘  要:目的采用颅脑高分辨率MRI正中矢状面图像测量0~14岁正常儿童胼胝体各径线值,探讨胼胝体与枕额径的相关性及性别差异。方法回顾性选择颅脑MRI检查结果正常的967例儿童影像学数据,按年龄段分组,以每1周岁为一组,共分14组,于颅脑正中矢状面测量胼胝体前后径(APD)、膝部厚度(GT)、体部厚度(BT)、峡部厚度(IT)、压部厚度(ST)以及枕额径(FOD)。在MRI颅脑正中矢状面图像上测量不同年龄儿童胼胝体各径线值,对14组胼胝体数据进行全面评估。采用直线回归和线性相关分析研究胼胝体各测量径线值与FOD的关系。将14组数据按性别分组,使用t检验进行统计分析,比较男孩组与女孩组各年龄组胼胝体各测量径线值及FOD差异是否有统计学意义,以P<0.05为差异具有统计学意义。结果儿童胼胝体各测量径线值随FOD的增加而增加,且与FOD呈正相关关系(均P<0.05)。利用14组各测量径线值,分别对男孩组和女孩组APD、GT、BT、IT、ST及FOD这6个数据共84个参数进行分析,其中有16个(19.0%)参数显示差异有统计意义,其中胼胝体各亚区厚度的性别差异集中在5~9岁,特别是5~6岁组,其GT、BT、IT、ST均显示出性别差异(均P<0.05),而FOD的性别差异集中在11~14岁;其余68个(80.9%)参数显示差异没有统计学意义。结论儿童胼胝体的各测量径线值与FOD呈正相关关系。性别因素的影响仅在部分年龄段的胼胝体部分亚区中呈现出差异,且存在一定规律(年龄集中趋势),可能反映不同年龄段、不同性别儿童在其认知能力上(如语言功能、运动协调能力等)的差异,为临床评估不同年龄、不同性别儿童发育情况提供一定参考依据。Objective To measure the diameters of the corpus callosum in normal children aged 0–14 years using the midsagittal plane of high-resolution magnetic resonance imaging(MRI),and to explore the correlation between the corpus callosum diameters and occipitofrontal diameter(FOD),as well as the gender differences.Methods A retrospective analysis was performed on the imaging data of 967 children with normal brain MRI results.The children were divided into 14 groups according to age,with each year of age as a group.The following measurements were taken on the midsagittal plane of the brain:anteroposterior diameter of the corpus callosum(APD),thickness of the genu(GT),thickness of the body(BT),thickness of the isthmus(IT),thickness of the splenium(ST),and occipitofrontal diameter(FOD).Linear regression and correlation analysis were used to study the relationship between the corpus callosum diameters and FOD.The 14 groups of data were further divided by gender,and statistical analysis using t-tests was performed to compare the corpus callosum diameters and FOD between boys and girls in each age group.A P-value of less than 0.05 was considered statistically significant.Results The diameters of the corpus callosum increased with increasing FOD and were positively correlated with FOD(all P-values<0.05).A total of 84 parameters(APD,GT,BT,IT,ST,and FOD)were analyzed across the 14 groups,and 16 of them(19%)showed statistically significant differences.The gender differences in the thickness of each subregion of the corpus callosum were concentrated in the 5-9 years old group,especially in the 5-6 years old group,where GT,BT,IT,and ST all showed gender differences(all P-values<0.05).The gender difference in FOD was concentrated in the 11-14 years old group.The remaining 68 parameters(81%)showed no statistically significant differences.Conclusion There is a positive correlation between the measured diameters of the corpus callosum and FOD in children.Gender differences in the corpus callosum subregions are only evident in certain

关 键 词:磁共振成像 儿童 胼胝体 性别差异 

分 类 号:R445.2[医药卫生—影像医学与核医学]

 

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