儿童肺炎支原体感染合并支气管哮喘患儿血清ET-1、IgE及Th17/Treg细胞比例变化和意义  

Changes and Significance of Serum ET-1,IgE and Th17/Treg Cell Ratio in Children with Mycoplasma Pneumoniae Infection Complicated with Bronchial Asthma

作　　者：周晓萍 ZHOU Xiaoping(Department of Pediatrics,Kunshan Traditional Chinese Medicine Hospital,Kunshan 215300,China)

机构地区：[1]昆山市中医医院儿科,昆山215300

出　　处：《宁夏医科大学学报》2025年第2期146-150,共5页Journal of Ningxia Medical University

摘　　要：目的探讨肺炎支原体感染合并支气管哮喘患儿血清内皮素-1(ET-1)、免疫球蛋白E(IgE)及辅助性T细胞17/调节性T细胞(Th17/Treg)比例变化和临床意义。方法回顾性分析肺炎支原体感染合并支气管哮喘患儿(观察组)和单纯支气管哮喘患儿(对照组)临床资料,比较两组ET-1、IgE、Th17细胞、Treg细胞、Th17/Treg以及肺功能潮气量(VT)、达峰时间/呼气时间(TPTEF/Te)、达峰容积/潮气量(VPTEF/VT)、峰值呼气流量(PEF)和第一秒最大呼气量占预计值百分比(FEV1%pred)差异,并且分析观察组不同肺炎严重程度患儿间上述指标的差异。结果观察组ET-1、IgE、Th17细胞和Th17/Treg均高于对照组(P均<0.05),而观察组Treg细胞低于对照组(P<0.05)。观察组VT、TPTEF/Te、VPTEF/VT、PEF和FEV1%pred均低于对照组(P均<0.05)。观察组重症患儿ET-1、IgE和Th17/Treg均高于轻症患儿(P均<0.05)。观察组重症患儿VT、TPTEF/Te、VPTEF/VT、PEF和FEV1%pred均低于轻症患儿(P均<0.05)。观察组ET-1、IgE、Th17/Treg与肺功能指标VT、TPTEF/Te、VPTEF/VT、PEF和FEV1%pred呈负相关(P均<0.05)。结论肺炎支原体感染合并支气管哮喘患儿血清ET-1、IgE及Th17/Treg与肺功能存在负相关关系。Objective To explore the changes and clinical significance of serum endothelin-1(ET-1),immunoglobulin E(IgE),and helper T cell 17/regulatory T cell(Th17/Treg)ratio in children with Mycoplasma pneumoniae infection complicated with bronchial asthma.Methods Mycoplasma pneumoniae infection combined with bronchial asthma treated were selected as the observation group,simple bronchial asthma were selected as the control group.The differences in ET-1,IgE,Th17 cells,Treg cells,Th17/Treg,as well as lung function tidal volume(VT),peak time to expiratory time(TPTEF/Te),peak volume to tidal volume(VPTEF/VT),peak expiratory flow(PEF),and percentage of first second maximum expiratory volume to predicted value(FEV1%pred)between the two groups were compared,as well as the differences between children with different severity levels in the observation group.Results The levels of ET-1,IgE,Th17 cells,and Th17/Treg in the observation group were higher than those in the control group(P all<0.05),while Treg cells were lower than those in the control group(P<0.05).The VT,TPTEF/Te,VPTEF/VT,PEF,and FEV1%pred in the observation group were lower than those in the control group(P all<0.05).The levels of ET-1,IgE and Th17/Treg in the observation group of critically ill children were higher than those in mild cases(P all<0.05).The VT,TPTEF/Te,VPTEF/VT,PEF and FEV1%in pred the observation group of critically ill children were lower than those in the mild cases(P all<0.05).The observation group showed a negative correlation between ET-1,IgE,Th17/Treg and lung function indicators VT,TPTEF/Te,VPTEF/VT,PEF and FEV1%pred(P all<0.05).Conclusion There is a negative correlation between the levels of ET-1,IgE and Th17/Treg cells and the lung function in children with Mycoplasma pneumoniae infection complicated with bronchial asthma.

关 键 词：肺炎支原体感染 支气管哮喘 内皮素-1 免疫球蛋白E 辅助性T细胞17/调节性T细胞 

分 类 号：R562.2[医药卫生—呼吸系统]