血清sST2、Gal-3表达对慢性心力衰竭患者发生心血管不良事件的预测价值  

Predictive value of serum soluble growth stimulating gene 2(sST2)and galectin-3(Gal-3)expression on cardiovascular adverse events in patients with chronic heart failure

作　　者：李欣 杨卓璇 LI Xin;YANG Zhuoxuan(Department of Cardiovascular Medicine,Shanxi Yuncheng Central Hospital,Yuncheng Shanxi 044000,China)

机构地区：[1]山西省运城市中心医院心血管内科,山西运城044000

出　　处：《新疆医科大学学报》2025年第4期499-503,共5页Journal of Xinjiang Medical University

基　　金：山西省应用基础研究计划项目(201901d211533);山西省卫生健康委课题项目(2022023)。

摘　　要：目的探讨慢性心力衰竭患者血清半乳糖凝集素-3(Gal-3)与可溶性生长刺激表达基因2(sST2)蛋白表达与心血管不良事件的关系,为降低慢性心衰患者心血管不良事件发生提供参考依据。方法选择2022年1月至2023年1月运城市中心医院收治的80例慢性心力衰竭患者,均进行12个月的随访,根据患者有无发生心血管不良事件分为发生组和未发生组,比较两组临床资料及实验室指标情况及分析血清Gal-3与sST2与心血管不良事件的关系。结果80例慢性心力衰竭患者随访期间发生心血管不良事件患者共计32例,占比40.00%(32/80)。其中,心律失常12例,占比37.50%(12/32);急性冠脉综合征10例,占比31.25%(10/32);急性心力衰竭10例,占比31.25%(10/32)。发生组血清Gal-3、sST2表达高于未发生组,差异有统计学意义(P<0.05);Logistic回归分析结果显示,血清Gal-3、sST2表达与患者心血管不良事件发生有关(OR=5.087、1.554,P均<0.05);受试者工作特征(ROC)曲线分析发现,血清Gal-3、sST2预测心血管不良事件的分别为0.937、0.949,两项指标联合预测曲线下面积(AUC)为0.980。结论血清Gal-3、sST2表达与慢性心力衰竭患者心血管不良事件的发生密切相关,血清Gal-3、sST2过表达可能是导致患者心血管不良事件发生风险增加的风险因子,且血清Gal-3、sST2表达越高,心血管不良事件发生风险越高。Objective To observe the relationship between the expression of serum galectin-3(Gal-3)and soluble growth stimulating expression gene 2(sST2)protein and adverse cardiovascular events in patients with chronic heart failure,so as to provide target reference for reducing the incidence of adverse cardiovascular events in patients with chronic heart failure.Methods A total of 80 patients with chronic heart failure admitted to the hospital from January 2022 to January 2023 were enrolled in the study.The enrolled patients were followed up for 12 months.The patients were divided into occurrence group and non-occurrence group according to the presence or absence of cardiovascular adverse events.The relationship between serum Gal-3 and sST2 and adverse cardiovascular events was analyzed.Results There were 32 patients with adverse cardiovascular events,accounting for 40.00%(32/80)during the follow-up period,including 12 cases of arrhythmia,accounting for 37.50%(12/32),10 cases of acute coronary syndrome,accounting for 31.25%(10/32),10 cases of acute heart failure.The proportion was 31.25%(10/32).The serum levels of Gal-3 and sST2 in the occurrence group were higher than those in the non-occurrence group,and the differences were statistically significant(P<0.05).The results of Logistic regression model showed that the serum levels of Gal-3 and sST2 were related to the occurrence of adverse cardiovascular events in patients(OR=5.087,1.554,P<0.05).The results of ROC showed that the AUC of serum Gal-3 and sST2 in predicting cardiovascular adverse events were 0.937,0.949,and the AUC of combined prediction was 0.980.Conclusion Serum Gal-3 and sST2 expression is closely related to the occurrence of adverse cardiovascular events in patients with chronic heart failure,and serum Gal-3 and sST2 overexpression may be a risk factor leading to an increased risk of adverse cardiovascular events in patients,and the higher the serum Gal-3 and sST2 expression,the higher the risk of adverse cardiovascular events.

关 键 词：慢性心力衰竭 半乳糖凝集素-3 可溶性生长刺激表达基因2蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]