强脉冲光联合重组牛碱性成纤维细胞生长因子在激素依赖性皮炎治疗中的应用效果及对患者皮肤屏障的影响  

Application effect of strong pulsed light combined with rb bFGF in the treatment of hormone-dependent dermatitis and its impact on the skin barrier of patients

作　　者：杜东亚 刘招娣 Du Dongya;Liu Zhaodi(Department of Dermatology and Venereology,Zhecheng Hospital of Integrated Chinese and Western Medicine,Henan 476200,China;不详)

机构地区：[1]河南省柘城县中西医结合医院皮肤科,476200 [2]商丘市中医院皮肤科

出　　处：《山西医药杂志》2025年第8期571-575,共5页Shanxi Medical Journal

摘　　要：目的探讨强脉冲光(IPL)联合重组牛碱性成纤维细胞生长因子(rb-BFGF)在激素依赖性皮炎(FCAD)患者中的应用效果及其对皮肤屏障功能的影响。方法前瞻性随机对照研究,选取2021年4月至2023年4月柘城县中西医结合医院收治的72例FCAD患者作为研究对象,随机数字表法分为对照组与观察组,每组各36例。对照组实施IPL治疗,4周1次;观察组予以IPL联合rb-BFGF治疗,2组均治疗4个月。对比2组应用效果,治疗前后屏障功能、免疫指标、生活质量水平以及不良反应与复发情况。结果治疗后,观察组客观症状及自主感受得分[(4.0±1.0)分、(2.1±1.0)分]低于对照组[(6.2±1.8)分、(6.2±1.8)分],差异有统计学意义(P<0.05)。观察组皮肤角质层含水量以及表皮皮脂含量[(43±4)%、(22±3)μg/cm^(3)]高于对照组[(40±5)%、(18±3)μg/cm^(3)],观察组经皮水分丢失(TEWL)(9.5±1.1)g·m^(-2)·h^(-1))低于对照组(10.8±2.7)g·m^(-2)·h^(-1)),差异有统计学意义(P<0.05)。治疗后,观察组CD4^(+)/CD8^(+)、CD4^(+)[(1.75±0.25)、(35.02±3.11)%]高于对照组[(1.30±0.31)、(31.85±2.96)%],观察组CD8^(+)(20.0±3.9)%低于对照组(24.6±4.0)%,差异有统计学意义(P<0.05)。观察组皮肤生活质量指数(DLQI)评分低于对照组[(10.6±1.7)分与(12.9±1.6)分],差异有统计学意义(P<0.05)。2组不良反应及复发比较,差异无统计学意义(P>0.05)。结论IPL联合rb-BFGF具有良好的治疗效果,能有效改善FCAD患者的皮肤屏障、免疫状态,提高生活质量水平,且具有较高的安全性。Objective To explore the application effect of intense pulsed light(IPL)combined with rec-ombinant bovine basic fibroblast growth factor(r-BFGF)in patients with hormone-dependent dermatitis(FCAD)and its impact on skin barrier function.Methods A prospective randomized controlled study was conducted,selecting 72 patients with FCAD admitted to Zhecheng Hospital of Integrated Chinese and Western Medicine from April 2021 to April 2023 as the research subjects.They were randomly divided into a control group and an observation group using a random number table method,with 36 patients in each group.The control group received IPL treatment once every 4 weeks.The observation group received IPL combined with rb-BFGF treatment,and both groups were treated for 4 months.Compare the application effects of two groups,including barrier function,immune indicators,quality of life,adverse reactions,and recurrence before and after treatment.Results After treatment,the objective symptoms and self-reported scores of the observation group[(4.0±1.0)points,(2.1±1.0)points]were lower than those of the control group[(6.2±1.8)points,(6.2±1.8)points],and the difference was statistically significant(P<0.05).After treatment,the water content of the stratum corneum and the sebum content of the epidermis in the observation group[(43±4)%,(22±3)μg/cm^(3)]were higher than those in the control group[(40±5)%,(18±3)μg/cm^(3)].The TEWL of the observation group(9.5±1.1)g·m^(-2)·h^(-1) was lower than that of the control group(10.8±2.7)g·m^(-2)·h^(-1),and the difference was statistically significant(P<0.05).After treatment,the CD4^(+)/CD8^(+)and CD4^(+)[(1.75±0.25),(35.02±3.11)%]in the observation group were higher than those in the control group[(1.30±0.31),(31.85±2.96)%],and the CD8^(+)(20.02±3.88)%in the observation group was lower than that in the control group(24.62±4.02)%,with statistical significance(P<0.05).After treatment,the DLQI scores in the observation group were lower than those in the control group[(10.6±1.7)points vs(

关 键 词：肿瘤 激素依赖性 强脉冲光疗法 成纤维细胞生长因子 临床疗效 

分 类 号：R751[医药卫生—皮肤病学与性病学]