急性ST段抬高心肌梗死患者心肌梗死面积与血清脑钠肽、25-羟维生素D3水平相关性研究  

A Study on the Correlation between Serum levels of Brain Natriuretic Peptide and 25-Hydroxyvitamin D3 with Myocardial Infarct Size in Patients with Acute ST-Segment Elevation Myocardial Infarction

作　　者：龚俊荣[1] 董佳敏 陈群[1] 陈文婷[1] GONG Jun-rong;DONG Jia-min;CHEN Qun;CHEN Wen-ting(Department of Cardiology,Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou Municipal Hospital,Suzhou,Jiangsu,215000,China)

机构地区：[1]南京医科大学附属苏州医院,苏州市立医院心内科,江苏苏州215000

出　　处：《中国血液流变学杂志》2024年第4期545-548,共4页Chinese Journal of Hemorheology

摘　　要：目的探讨急性ST段抬高心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者血清生化指标脑钠肽(brain natriuretic peptide,BNP)、血清25-羟维生素D3(25-hydroxyvitamin D3,25(OH)D3)浓度与心肌梗死面积的相关性。方法选择2020年02月—2024年02月苏州市立医院诊治的150例STEMI患者为研究对象,比较所有患者入院时和术后1周血清BNP浓度、25(OH)D3浓度和心肌梗死面积,并采用Pearson相关性系数分析患者心肌梗死面积与血清BNP浓度、25(OH)D3浓度相关性,按照早期心血管事件分组,对比血清BNP浓度、25(OH)D3浓度。结果患者入院时与术后1周的BNP浓度、25(OH)D3浓度和心肌梗死面积差异具有统计学意义(P<0.05)。患者心肌梗死面积与血清BNP浓度呈现正相关(r=0.65,P<0.05),与25(OH)D3浓度呈现显著负相关(r=-0.73,P<0.05)。心肌梗死患者发生心肌梗死再发4例、心力衰竭27例、死亡4例,其中发生死亡、心力衰竭患者BNP浓度均显著高于未发生组(P<0.05),而25(OH)D3浓度均显著低于未发生组,心肌梗死再发患者与未发生组在BNP浓度和25(OH)D3浓度差异无统计学意义(P>0.05)。结论血清BNP、25(OH)D3水平与心肌梗死面积具有一定的相关性,心肌梗死的面积越大,BNP表达水平越高、25(OH)D3水平越低;BNP、25(OH)D3水平对于心肌梗死后早期心血管事件具有风险提示价值。Objective To investigate the correlation between serum biochemical indexes of brain natriuretic peptide(BNP),25-hydroxyvitamin D3(25(OH)D3)levels and myocardial infarction area in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods 150 STEMI patients diagnosed and treated in Suzhou Municipal Hospital from February 2020 to February 2024 were selected for the study,and serum BNP concentration,25(OH)D3 concentration,and myocardial infarction area were compared between all the patients at the time of admission to the hospital and one week after surgery.Pearson correlation coefficient was used to analyze the correlation between myocardial infarction area and serum BNP concentration and 25(OH)D3 concentration of the patients.Serum BNP concentration and 25(OH)D3 concentration were compared according to the grouping of early cardiovascular events.Results There was a significant difference in BNP concentration,25(OH)D3 concentration and myocardial infarct area between patients at admission and one week after surgery(P<0.05).The patients'myocardial infarction area showed a significant positive correlation with serum BNP concentration(r=0.65,P<0.05)and a significant negative correlation with 25(OH)D3 concentration(r=-0.73,P<0.05).Arnong myocardial infarction patients,there were 4 cases of recurrence,27 cases of heart failure,and 5 cases of death.BNP concentrations of patients with death and heart failure were significantly higher than those of the non-occurrence group(P<0.05),and the 25(OH)D3 concentration was significantly lower than that of the non-occurrence group,and there was no significant difference between patients with recurrent myocardial infarction and those with non-occurrence in terms of the BNP concentration and 25(OH)D3 concentration(P>0.05).Conclusion Serum BNP and 25(OH)D3 levels have a certain correlation with the area of myocardial infarction,the larger the area of myocardial infarction,the higher the level of BNP and the lower the level of 25(OH)D3.BNP and 25(OH)D3 levels have r

关 键 词：BNP 25(OH)D3 急性ST段抬高型心肌梗死 梗死面积 

分 类 号：R542.22[医药卫生—心血管疾病]