拉贝洛尔辅助治疗对妊娠期高血压患者凝血功能及脐动脉血流指标的影响  

Effect of Labetalol Adjuvant Therapy on Coagulation and Umbilical Artery Flow Indices in Hypertensive Patients during Pregnancy

作　　者：张海芬 胡伟冰 林燕萍 ZHANG Hai-fen;HU Wei-bing;LIN Yan-ping(Department of Obstetrics and Gynecology,Hui'an Maternal and Child Health Hospital,Hui'an,Fujian,362100,China)

机构地区：[1]福建省惠安县妇幼保健院妇产科,福建惠安362100

出　　处：《中国血液流变学杂志》2024年第4期588-591,611,共5页Chinese Journal of Hemorheology

摘　　要：目的探究拉贝洛尔辅助治疗对妊娠期高血压患者凝血功能及脐动脉血流指标的影响。方法选取惠安县妇幼保健院妇产科2021年8月—2024年4月收治的妊娠期高血压患者共80例,根据随机数字法将其分为对照组(硫酸镁,n=39)和观察组(硫酸镁联合拉贝洛尔,n=41)。对比两组临床疗效、凝血功能[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)]、脐动脉血流指标、血压、肾功能情况[胱抑素C(CysC)、24 h尿蛋白]以及不良反应发生情况。结果观察组(92.68%)临床总有效率比对照组高(76.92%)(P<0.05);与治疗前相比较,观察组与对照组的PT、TT、APTT时间均得以有效延长,而FIB水平、收缩压、舒张压、CysC水平、24 h尿蛋白量则呈下降趋势,且观察组PT、TT、APTT延长时间比对照组长,FIB水平、收缩压、舒张压、CysC水平、24 h尿蛋白量下降程度比对照组高(P<0.05);治疗后,两组收缩压与舒张压血流锋速比值、血浆黏度、血细胞压积、阻力指数均下降,且观察组比对照组低(P<0.05);观察组(19.49%)不良反应发生率低于对照组(33.33%)(P>0.05)。结论在妊娠期高血压患者中,应用硫酸镁联合拉贝洛尔治疗可有效改善血压、凝血功能以及脐动脉血流指标,且具有较好的临床疗效和安全性。Objective To investigate the effect of Labetalol adjuvant therapy on coagulation and umbilical artery flow indices in hypertensive patients during pregnancy.Methods 80 patients with gestational hypertension admitted to Hui'an Maternal and Child Health Hospital from August 2021 to April 2024 were selected for the study,and were divided into the control group(Magnesium Sulphate,n=39)and the observation group(Magnesium Sulphate+Labetalol,n=41)according to the different treatment modalities.The clinical efficacy,coagulation function[prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(FIB)],umbilical artery blood flow index,blood pressure,renal function[cystatin C(CysC),24 h urine protein]and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of observation group(92.68%)was higher than that of control group(76.92%)(P<0.05).Compared with before treatment,PT,TT and APTT time in observation group and control group were effectively prolonged,while FIB level,systolic blood pressure,diastolic blood pressure,CysC level and 24 h urinary protein volume showed a downward trend.And PT,TT and APTT prolonged time in observation group was longer than that in control group,FIB level,systolic blood pressure,diastolic blood pressure,CysC level and 24 h urinary protein volume decreased more in observation group than in control group(P<0.05).After treatment,systolic and diastolic blood flow velocity ratio,plasma viscosity,hematocrit,and resistance index decreased in both groups,and the observation group was lower than the control group(P<0.05).The incidence of adverse reactions in observation group(19.49%)was lower than that in control group(33.33%)(P>0.05).Conclusion Magnesium Sulfate combined with Labetalol treatment can effectively improve blood pressure,coagulation function,and umbilical artery blood flow indexes in patients with gestational hypertension,and has good clinical efficacy and safety.

关 键 词：拉贝洛尔 妊娠期高血压 凝血功能 脐动脉血流 

分 类 号：R714.246[医药卫生—妇产科学]