344例H3N2型流感住院患儿的临床特征及外周血检查结果的分析  

Clinical Characteristics and Peripheral Blood Laboratory Results of 344 Hospitalized Children with H3N2 Influenza A Virus

作　　者：邓建萍 田健美[1] 成芳芳[1] 陈庆会[1] 车琳[1] 石婷[1] DENG Jian-ping;TIAN Jian-mei;CHENG Fang-fang;CHEN Qing-hui;CHE Lin;SHI Ting(Department of Infectious Diseases,Children's Hospital of Soochow University,Suzhou,Jiangsu,215003,China)

机构地区：[1]苏州大学附属儿童医院感染性疾病科,江苏苏州215003

出　　处：《中国血液流变学杂志》2024年第4期596-600,共5页Chinese Journal of Hemorheology

基　　金：江苏省卫生健康委2023年度医学科研重点项目(K2023049)。

摘　　要：目的探讨因H3N2甲型流感病毒感染住院儿童的临床特征及外周血检查结果,以加深儿科医生对疾病认识。方法回顾性分析2022年1月—2022年12月苏州大学附属儿童医院收治的344例H3N2流感病毒感染患儿的临床资料。根据病情严重程度将纳入的患儿分为普通组和重症组,比较两组的临床特点及外周血检查结果。结果2022年H3N2型流感病例集中于6月至12月,学龄前儿童为感染高发人群,男女儿童均易感。主要症状是发热、咳嗽,呼吸系统并发症为主要住院原因。对比普通组患儿,重症组患儿淋巴细胞计数、CD4+、CD8+细胞下降(P<0.05);超敏肌钙蛋白T(hs-TnT)、活化部分凝血活酶时间(APTT)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)升高(P<0.05),且平均住院时间长。两组患儿经积极治疗后,均好转出院。结论此次H3N2型流感于夏秋季高发,可能与新冠疫情防控相关。重症患儿的细胞免疫损害更明显;当患儿出现hs-TnT、APTT、ALT、AST升高时需警惕重症可能。积极治疗后,H3N2型流感的预后较好。Objective To investigate the clinical characteristics and peripheral blood laboratory findings of hospitalized children infected with the H3N2 influenza A virus,thereby enhancing pediatricians'comprehension of this disease.Methods This study reviewed 344 children infected with H3N2 influenza A virus who were hospitalized at Children's Hospital of Soochow University from January to December 2022.According to the patient's condition,they were divided into a mild group and a severe group.The clinical manifestations and peripheral blood laboratory results were analyzed and compared.Results In 2022,the H3N2 influenza A virus infection predominantly occurred from June to December,primarily affecting preschoolers.Both male and female children exhibit equal susceptibility.Main symptoms were fever and cough.Respiratory complications were the main reason for patients hospitalized.Compare with the mild group,the values of lymphocytes,CD4+,CD8+were significantly lower in severe group(P<0.05).Additionally,the levels of high-sensitivity troponin T(hs-TnT),activated partial thromboplastin time(APTT),alanine aminotransferase(ALT)and aspartate aminotransferase(AST)were significantly higher in the severe group than in the mild group(P<0.05).Mean duration of hospitalization in the severe group was longer than that in the mild group.All patients were discharged from hospital following their treatment.Conclusion H3N2 influenza was prevalent during the summer and autumn of 2022,which may be due to the COVID-19 prevention and control measures.Children with severe illness show more significant impair of cellular immunity.Elevated levels of hs-TnT,APTT,ALT and AST in patients could indicate severe illness.Children infected with the H3N2 influenza A virus demonstrates a favorable prognosis following active treatment.

关 键 词：儿童 H3N2甲型流感 临床特征 重症流感 

分 类 号：R725.1[医药卫生—儿科]