点阵CO_(2)激光联合黄芩油膏外用治疗增生性瘢痕的疗效及安全性  

Efficacy and safety of fractional CO_(2) laser combined with topical application of radix scutellariae ointment in treatment of hyperplastic scar

作　　者：付秋悦 张天琦 陈威 张杉 陈浩 周莉娜[2] 陈刚 Fu Qiuyue;Zhang Tianqi;Chen Wei;Zhang Shan;Chen Hao;Zhou Lina;Chen Gang(Department of Plastic Surgery,Affiliated Hospital of Nanjing University of Chinese Medicine(Jiangsu Province Hospital of Chinese Medicine),Nanjing 210029,China;Department of Plastic Surgery,Zhangjiagang Affiliated Hospital of Nanjing University of Chinese Medicine(Zhangjiagang Hospital of Traditional Chinese Medicine),Zhangjiagang 215699,China)

机构地区：[1]南京中医药大学附属医院(江苏省中医院)整形外科,南京210029 [2]南京中医药大学附属张家港医院(张家港市中医医院)整形外科,张家港215699

出　　处：《中华医学美学美容杂志》2025年第2期126-130,共5页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：江苏省卫生健康委面上项目(BJ20023)。

摘　　要：目的观察点阵CO_(2)激光联合黄芩油膏外用治疗增生性瘢痕的临床疗效及安全性。方法本研究为随机对照试验,前瞻性纳入2020年1月至2021年12月南京中医药大学附属医院(江苏省中医院)进行点阵CO_(2)激光治疗增生性瘢痕的患者90例,采用随机数字表法分为试验组和对照组。试验组45例,男22例,女23例,年龄18~54岁;使用点阵CO_(2)激光治疗后于创面涂抹黄芩油膏。对照组45例,男23例,女22例,年龄19~55岁;使用点阵CO_(2)激光治疗后于创面涂抹重组牛碱性成纤维细胞生长因子凝胶。患者每3个月接受1次治疗,并于治疗后1个月观察患者瘢痕情况。比较两组患者治疗后温哥华瘢痕量表(VSS)评分及瘢痕美容评估与评级量表(SCAR)评分,记录不良反应发生率,评估患者满意度。结果第1次、第2次、第3次治疗后,试验组VSS评分及SCAR评分均低于对照组,差异均有统计学意义(均P<0.05)。试验组患者满意度为91.1%(41/45),高于对照组的77.8%(35/45,P=0.036)。试验组患者不良反应发生率为15.6%(7/45),对照组为28.9%(13/45),差异无统计学意义(P=0.813)。结论点阵CO_(2)激光联合黄芩油膏外用治疗增生性瘢痕具有较好的临床疗效,患者满意度较高,不良反应发生率较低。Objective To evaluate the clinical efficacy and safety of fractional CO_(2) laser combined with topical application of radix scutellariae ointment in the treatment of hyperplastic scar.Methods This randomized controlled trial prospectively enrolled 90 patients with hyperplastic scar treated with fractional CO_(2) laser at the Affiliated Hospital of Nanjing University of Chinese Medicine(Jiangsu Province Hospital of Chinese Medicine)from January 2020 to December 2021.Participants were randomly divided into a trial group and a control group using a random number table.The trial group(n=45,22 males,23 females,aged 18-54 years)received topical radix scutellariae ointment post-laser treatment,while the control group(n=45,23 males,22 females,aged 19-55 years)received recombinant bovine basic fibroblast growth factor gel.Both groups underwent treatment every 3 months,with scar assessments conducted at 1-month post-treatment.Outcomes included Vancouver scar scale(VSS)scores,scar cosmesis assessment and rating(SCAR)scores,adverse reaction rates,and patients'satisfaction.Results After the first,second,and third treatments,the trial group showed significantly lower VSS and SCAR scores compared to the control group(all P<0.05).Patients'satisfaction in the trial group was 91.1%(41/45),significantly higher than 77.8%(35/45)in the control group(P=0.036).The adverse reaction rate in the trial group was 15.6%(7/45),and 28.9%(13/45)in the control group,there was no statistical difference(P=0.813).Conclusion Fractional CO_(2) laser combined with topical radix scutellariae ointment demonstrate superior clinical efficacy,higher patient satisfaction,and lower adverse reaction rates in the treatment of hyperplastic scar.

关 键 词：增生性瘢痕 点阵CO_(2)激光 黄芩油膏 

分 类 号：R622[医药卫生—整形外科]