强脉冲光联合屏障特护霜治疗玫瑰痤疮的效果  

Effect of intense pulsed light combined with barrier cream for rosacea treatment

作　　者：景文文 梁永辉 刘悦如 Jing Wenwen;Liang Yonghui;Liu Yueru(Department of Dermatology,Xianyang Central Hospital of Shaanxi Province,Xianyang 712000,China)

机构地区：[1]陕西省咸阳市中心医院皮肤科,咸阳712000

出　　处：《中华医学美学美容杂志》2025年第2期143-147,共5页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：陕西省社会发展科技攻关项目(2016SF-222)。

摘　　要：目的探讨强脉冲光联合屏障特护霜治疗玫瑰痤疮的效果。方法回顾性纳入2021年2至4月陕西省咸阳市中心医院玫瑰痤疮患者82例,根据不同治疗方法分为两组:观察组47例,采用强脉冲光联合屏障特护霜治疗,包括男22例,女25例,年龄22~40(30.6±4.2)岁;对照组35例,采用强脉冲光治疗,其中男19例,女16例,年龄20~42(31.1±5.0)岁。两组患者均持续治疗4个月后观察疗效。比较两组患者临床症状评分、总有效率、皮肤生理指标(角质层含水量、皮肤油脂含量)及不良反应发生率。结果治疗4个月后,观察组临床症状评分为(4.0±0.6)分,低于对照组的(4.5±0.7)分(P<0.001)。观察组总有效率为95.7%(45/47),高于对照组的80.0%(28/35,P=0.024)。观察组角质层含水量和皮肤油脂含量均高于对照组(均P<0.05)。对照组不良反应发生率为22.9%(8/35),观察组为6.4%(3/47),差异有统计学意义(P=0.030)。结论强脉冲光联合屏障特护霜治疗玫瑰痤疮可改善患者临床症状,且安全性较好。Objective To explore the effect of intense pulsed light combined with barrier special care cream in the treatment of rosacea.Methods A retrospective study was performed for 82 patients with rosacea in Xianyang Central Hospital of Shaanxi Province from February to April 2021,and they were divided into two groups according to different treatment methods:47 cases in the observation group,treated with intense pulsed light combined with barrier special cream,including 22 males and 25 females,aged 22-40(30.6±4.2)years;in the control group,35 cases were treated with intense pulsed light,including 19 males and 16 females,aged 20-42(31.1±5.0)years.The efficacy of treatment was observed after 4 months of continuous treatment in both groups.The clinical symptom score,total effective rate,skin physiological indexes(stratum corneum water content,skin oil content)and incidence of adverse reactions were compared between the two groups.Results After 4 months of treatment,the clinical symptom score of the observation group was(4.0±0.6),which was lower than that of the control group(4.5±0.7)(P<0.001).The total effective rate of the observation group was 95.7%(45/47),which was higher than that(80.0%,28/35)of the control group(P=0.024).The water content of stratum corneum and skin oil content in the observation group were higher than those in the control group(all P<0.05).The incidence of adverse reactions was 22.9%(8/35)in the control group and 6.4%(3/47)in the observation group,and the difference was statistically significant(P=0.030).Conclusion Intense pulsed light combined with barrier cream for the treatment of rosacea can improve the clinical symptoms of patients and has a good safety profile.

关 键 词：玫瑰痤疮 强脉冲光治疗 屏障特护霜 治疗结果 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]