中青年人群中生活方式与血清氧化应激标志物水平关系的研究  

Study on the relationship between lifestyle and serum levels of oxidative stress markers in the young and middle-aged individuals

作　　者：宋加怡 袁坤 李崇剑[2] 楚军民[3] 黄宜林 东黎光[5] 穆琳 田小园 王宏宇[8] 刘金波[8] 安欣华 杨瑛 田野[1] 王增武[1] 张林峰[1] SONG Jia-yi;YUAN Kun;LI Chong-jian;CHU Jun-min;HUANG Yi-lin;DONG Li-guang;MU Lin;TIAN Xiao-yuan;WANG Hong-yu;LIU Jin-bo;AN Xin-hua;YANG Ying;TIAN Ye;WANG Zeng-wu;ZHANG Lin-feng(Division of Prevention and Community Health,Chinese Academy of Medical Sciences,Peking Union Medical College,National Center for Cardiovascular Diseases,Fuwai Hospital,Beijing 100032,China;Coronary Heart Disease Center,Chinese Academy of Medical Sciences,Peking Union Medical College,National Center for Cardiovascular Diseases,Fuwai Hospital,Beijing 100032,China;Adult Cardiac Surgery Center,Chinese Academy of Medical Sciences,Peking Union Medical College,National Center for Cardiovascular Diseases,Fuwai Hospital,Beijing 100032,China;Department of Medical Statistics,Chinese Academy of Medical Sciences,Peking Union Medical College,National Center for Cardiovascular Diseases,Fuwai Hospital,Beijing 100032,China;Health Management Center,Shougang Hospital,Peking University,Beijing 100144,China;Department of Preventive Health Care,Pingguoyuan Community Health Service Center,Beijing 100041,China;Department of Family Medicine,Wulituo Community Health Service Center,Beijing 100042,China;Department of Vascular Medicine,Shougang Hospital,Peking University,Beijing 100144,China;Department of Health Education,Center for Disease Control and Prevention,Shijingshan District,Beijing 100043,China;Heart Center,The First Affiliated Hospital of Tsinghua University,Beijing 100016,China)

机构地区：[1]中国医学科学院北京协和医学院国家心血管病中心阜外医院社区防治部,北京市100032 [2]中国医学科学院北京协和医学院国家心血管病中心阜外医院冠心病中心,北京市100032 [3]中国医学科学院北京协和医学院国家心血管病中心阜外医院成人心脏外科中心,北京市100032 [4]中国医学科学院北京协和医学院国家心血管病中心阜外医院医学统计部,北京市100032 [5]北京大学首钢医院健康管理中心 [6]石景山区苹果园社区卫生服务中心预防保健科 [7]石景山区五里坨社区卫生服务中心全科医学科 [8]北京大学首钢医院血管医学科 [9]石景山区疾病预防控制中心健康教育科 [10]清华大学第一附属医院心脏中心

出　　处：《中国心血管病研究》2025年第4期373-379,共7页Chinese Journal of Cardiovascular Research

基　　金：国家自然科学基金(81973117)。

摘　　要：目的 探究中青年人群中生活方式与人体主要氧化应激标志物水平的关系。方法 于2022年1月和2023年8至9月随机抽取北京市石景山区苹果园和五里坨街道18岁以上居民进行问卷调查、体格检查,并留取空腹静脉血进行实验室检测。利用多元线性回归分析多种生活方式变量与血清氧化应激标志物之间的关联。结果 研究共纳入651例18岁以上55以下的中青年,其中男性338例(51.9%),女性313例(48.1%)。相关性分析显示,多种生活方式与血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶3(GPX3)、丙二醛(MDA)、氧化型低密度脂蛋白(oxLDL)和对氧磷酶(PON1)这5种标志物水平之间存在显著关联。采用多元线性回归模型控制可能的混杂因素进行分析的结果显示,睡眠时间与SOD活性、吸烟和蛋类摄入量与GPX3浓度、中等及以上体力活动时间与oxLDL浓度呈正相关(β=0.029、52.514、0.363、0.004,P<0.05),睡眠时间与MDA、蛋类摄入和睡眠时间与oxLDL、吸烟和睡眠时间与PON1呈负相关(β=-0.031、-0.005、-0.007、-5.043、-0.040,P<0.05)。这些关联在按性别分层的人群中也有体现。结论 生活方式与中青年人群体内常见的氧化应激标志物水平息息相关,中青年人群可以通过改善生活方式来调节身体的氧化应激状态。Objective To explore the relationship between lifestyle and major oxidative stress biomarkers in young and middle-aged individuals.Methods In January 2022 and from August to September 2023,a random sample of residents aged 18 years and above was selected from the Pingguoyuan and Wulituo Street in Shijingshan District,Beijing for questionnaire survey and physical examination,and fasting venous blood was collected for laboratory testing.Multiple linear regression analysis was used to explore associations between the lifestyle variables and serum oxidative stress biomarkers.Results A total of 651 young and middle-aged individuals aged18-54 years were included in this study,including 338 males(51.9%) and 313 females(48.1%).Correlation analysis showed significant associations between several lifestyle factors and the levels of five oxidative stress biomarkers:superoxide dismutase(SOD),glutathione peroxidase 3(GPX3),malondialdehyde(MDA),oxidized low-density lipoprotein(oxLDL) and paraoxonase 1(PON1).After adjusting for confounders in multiple linear regression models,sleep duration was found to be positively correlated with SOD activity,while smoking and egg consumption were positively correlated with GPX3 levels,and moderate or greater physical activity was positively correlated with oxLDL levels(β=0.029,52.514,0.363,0.004,P<0.05).Conversely,sleep duration was negatively correlated with MDA levels,egg consumption and sleep duration were negatively correlated with oxLDL levels,and smoking and sleep duration were negatively correlated with PON1 levels(β =-0.031,-0.005,-0.007,-5.043,-0.040,P<0.05).These associations were also observed in the sex-stratified analysis.Conclusion Lifestyle is closely related to the levels of common oxidative stress biomarkers in the bodies of the young and middle-aged people.Young and middle-aged individuals can regulate their oxidative stress status by improving their lifestyle.

关 键 词：生活方式 氧化应激 血清标志物 中青年人群 

分 类 号：R54[医药卫生—心血管疾病]