复方江南卷柏汤联合西药治疗湿热蕴结型急性痛风性关节炎临床观察  

Clinical observation of compound Jiangnanjuanbai decoction combined with western medicine treating acute gouty arthritis with damp-heat accumulation syndrome

作　　者：胡浩 戴新华 张梦婷 Hu Hao;Dai Xinhua;Zhang Mengting(Huanggang Hospital of Traditional Chinese Medicine,Huanggang,Hubei,438000)

机构地区：[1]黄冈市中医医院,湖北黄冈438000

出　　处：《广西中医药》2025年第2期10-14,共5页Guangxi Journal of Traditional Chinese Medicine

基　　金：黄冈市级科技创新专项前资助项目(编号:YBXM20240044)。

摘　　要：目的:观察复方江南卷柏汤联合双氯芬酸钠缓释胶囊治疗湿热蕴结型急性痛风性关节炎(AGA)的临床效果。方法:选取120例湿热蕴结型AGA患者,采用随机数字表法将其分为对照组、中医组及中西医组,每组40例。对照组予口服双氯芬酸钠缓释胶囊治疗,中医组予口服复方江南卷柏汤治疗,中西医组则予口服双氯芬酸钠缓释胶囊及复方江南卷柏汤治疗,三组疗程均为1周。观察并比较三组患者治疗前后的疼痛视觉模拟量表(VAS)评分、中医证候(关节肿胀、关节疼痛、关节灼热)评分、血尿酸(UA)及炎症指标[包括白细胞(WBC)计数、C反应蛋白(CRP)、红细胞沉降率(ESR)]水平,比较三组疗效、不良反应发生情况。结果:对照组总有效率为77.5%,中医组总有效率为75.0%,中西医组总有效率为85.0%,三组疗效比较差异无统计学意义(P>0.05)。治疗后,三组患者疼痛VAS评分、中医证候评分、UA及炎症指标水平均较治疗前降低,且中西医组患者疼痛VAS评分、关节肿胀评分、关节疼痛评分及CRP、ESR水平低于对照组及中医组,UA水平低于对照组(均P<0.05)。三组不良反应发生率均为2.5%,三组不良反应发生率比较差异无统计学意义(P>0.05)。结论:复方江南卷柏汤联合双氯芬酸钠缓释胶囊治疗湿热蕴结型急性痛风性关节炎可减轻患者临床症状,降低UA水平,抑制炎症反应且安全性较高,值得临床推广应用。Objective:To evaluate the clinical efficacy of compound Jiangnanjuanbai decoction,when used in combination with diclofenac sodium sustained-release capsules,in treating acute gouty arthritis(AGA)with a dampheat accumulation syndrome.Methods:A total of 120 patients diagnosed with AGA and presenting with damp-heat ac⁃cumulation syndrome were randomly allocated into three groups:control group,traditional Chinese medicine(TCM)group,and integrated TCM-Western medicine group,with 40 patients in each group.Patients in the control group re⁃ceived oral diclofenac sodium sustained-release capsules,those in the TCM group were orally administered compound Jiangnanjuanbai decoction,and patients in the integrated group received both treatments concurrently.The treatment in all groups lasted for one week.Visual analog scale(VAS)scores for pain,TCM syndrome scores(including joint swelling,joint pain,and joint burning sensation),and levels of serum uric acid(UA)as well as levels of inflammatory markers,including white blood cell(WBC)count,C-reactive protein(CRP)levels,and erythrocyte sedimentation rate(ESR)were measured before and after the treatment.The therapeutic outcomes and the incidence of adverse reactions were compared across the three groups.Result:The total effective rates were 77.5%in the control group,75.0%in the TCM group,and 85.0%in the integrated group.No significant differences in efficacy were observed among the three groups(P>0.05).Following treatment,all three groups demonstrated reductions in pain VAS scores,TCM syndrome scores,UA levels,and inflammatory marker levels.Notably,the integrated group exhibited significantly lower pain VAS scores,joint swelling scores,joint pain scores,CRP levels,and ESR levels compared to the control and TCM group,and lower UA levels compared to the control group(all P<0.05).The incidence of adverse reactions was 2.5%in all three groups,with no statistically significant differences among them(P>0.05).Conclusion:The combination therapy of compound Jiangnanjuanbai decoction and

关 键 词：急性痛风性关节炎 复方江南卷柏汤 湿热蕴结型 临床观察 

分 类 号：R259[医药卫生—中西医结合]